Cited 16 times in
Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results
DC Field | Value | Language |
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dc.contributor.author | 장진우 | - |
dc.date.accessioned | 2024-03-22T06:03:58Z | - |
dc.date.available | 2024-03-22T06:03:58Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 0022-3085 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198371 | - |
dc.description.abstract | OBJECTIVE The objective of this study was to evaluate, at 4 and 5 years posttreatment, the long-term safety and efficacy of unilateral MRI-guided focused ultrasound (MRgFUS) thalamotomy for medication-refractory essential tremor in a cohort of patients from a prospective, controlled, multicenter clinical trial. METHODS Outcomes per the Clinical Rating Scale for Tremor (CRST), including postural tremor scores (CRST Part A), combined hand tremor/motor scores (CRST Parts A and B), and functional disability scores (CRST Part C), were measured by a qualified neurologist. The Quality of Life in Essential Tremor Questionnaire (QUEST) was used to assess quality of life. CRST and QUEST scores at 48 and 60 months post-MRgFUS were compared to those at baseline to assess treatment efficacy and durability. All adverse events (AEs) were reported. RESULTS Forty-five and 40 patients completed the 4- and 5-year follow-ups, respectively. CRST scores for postural tremor (Part A) for the treated hand remained significantly improved by 73.3% and 73.1% from baseline at both 48 and 60 months posttreatment, respectively (both p < 0.0001). Combined hand tremor/motor scores (Parts A and B) also improved by 49.5% and 40.4% (p < 0.0001) at each respective time point. Functional disability scores (Part C) increased slightly over time but remained significantly improved through the 5 years (p < 0.0001). Similarly, QUEST scores remained significantly improved from baseline at year 4 (p < 0.0001) and year 5 (p < 0.0003). All previously reported AEs remained mild or moderate, and no new AEs were reported. CONCLUSIONS Unilateral MRgFUS thalamotomy demonstrates sustained and significant tremor improvement at 5 years with an overall improvement in quality-of-life measures and without any progressive or delayed complications. © 2023 The authors. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | American Association of Neurological Surgeons | - |
dc.relation.isPartOf | JOURNAL OF NEUROSURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Essential Tremor* / diagnostic imaging | - |
dc.subject.MESH | Essential Tremor* / surgery | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging / methods | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Quality of Life | - |
dc.subject.MESH | Thalamus / diagnostic imaging | - |
dc.subject.MESH | Thalamus / surgery | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Tremor | - |
dc.title | Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | G Rees Cosgrove | - |
dc.contributor.googleauthor | Nir Lipsman | - |
dc.contributor.googleauthor | Andres M Lozano | - |
dc.contributor.googleauthor | Jin Woo Chang | - |
dc.contributor.googleauthor | Casey Halpern | - |
dc.contributor.googleauthor | Pejman Ghanouni | - |
dc.contributor.googleauthor | Howard Eisenberg | - |
dc.contributor.googleauthor | Paul Fishman | - |
dc.contributor.googleauthor | Takaomi Taira | - |
dc.contributor.googleauthor | Michael L Schwartz | - |
dc.contributor.googleauthor | Nathan McDannold | - |
dc.contributor.googleauthor | Michael Hayes | - |
dc.contributor.googleauthor | Susie Ro | - |
dc.contributor.googleauthor | Binit Shah | - |
dc.contributor.googleauthor | Ryder Gwinn | - |
dc.contributor.googleauthor | Veronica E Santini | - |
dc.contributor.googleauthor | Kullervo Hynynen | - |
dc.contributor.googleauthor | W Jeff Elias | - |
dc.identifier.doi | 10.3171/2022.6.JNS212483 | - |
dc.contributor.localId | A03484 | - |
dc.relation.journalcode | J01636 | - |
dc.identifier.eissn | 1933-0693 | - |
dc.identifier.pmid | 35932269 | - |
dc.subject.keyword | MRI | - |
dc.subject.keyword | essential tremor | - |
dc.subject.keyword | focused ultrasound | - |
dc.subject.keyword | functional neurosurgery | - |
dc.subject.keyword | thalamotomy | - |
dc.contributor.alternativeName | Chang, Jin Woo | - |
dc.contributor.affiliatedAuthor | 장진우 | - |
dc.citation.volume | 138 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1028 | - |
dc.citation.endPage | 1033 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROSURGERY, Vol.138(4) : 1028-1033, 2023-08 | - |
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