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Liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma: A multicenter study
DC Field | Value | Language |
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dc.contributor.author | 주동진 | - |
dc.date.accessioned | 2024-03-22T06:03:27Z | - |
dc.date.available | 2024-03-22T06:03:27Z | - |
dc.date.issued | 2023-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198365 | - |
dc.description.abstract | BACKGROUNDPatients with combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) are not traditionally considered eligible for liver transplantation (LT) due to poor outcomes.AIMTo compare outcomes between living donor LT (LDLT) patients with hepatocellular carcinoma (HCC) and LT patients with cHCC-CC and to identify risk factors for tumor recurrence and death after LT in cHCC-CC patients.METHODSData for pathologically diagnosed cHCC-CC patients (n = 111) who underwent LT from 2000 to 2018 were collected for a nine-center retrospective review. Patients (n = 141) who received LDLT for HCC at Samsung Medical Center from January 2013 to March 2017 were selected as the control group. Seventy patients in two groups, respectively, were selected by 1:1 matching.RESULTSCumulative disease-free survival (DFS) and overall survival (OS) in the cHCC-CC group were significantly worse than in the HCC group both before and after matching. Extrahepatic recurrence incidence in the cHCC-CC group was higher than that in the HCC group (75.5% vs 33.3%, P < 0.001). Multivariate analysis demonstrated that the cHCC-CC group had significantly higher rates of tumor recurrence and death compared to the HCC group. In cHCC-CC subgroup analysis, frequency of locoregional therapies > 3, tumor size > 3 cm, and lymph node metastasis were predisposing factors for tumor recurrence in multivariate analysis. Only a maximum tumor size > 3 cm was a predisposing factor for death.CONCLUSIONThe poor prognosis of patients diagnosed with cHCC-CC after LT can be predicted based on the explanted liver. Frequent regular surveillance for cHCC-CC patients should be required for early detection of tumor recurrence. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Baishideng | - |
dc.relation.isPartOf | WORLD JOURNAL OF GASTROINTESTINAL SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma: A multicenter study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Jongman Kim | - |
dc.contributor.googleauthor | Dong-Jin Joo | - |
dc.contributor.googleauthor | Shin Hwang | - |
dc.contributor.googleauthor | Jeong-Moo Lee | - |
dc.contributor.googleauthor | Je-Ho Ryu | - |
dc.contributor.googleauthor | Yang-Won Nah | - |
dc.contributor.googleauthor | Dong-Sik Kim | - |
dc.contributor.googleauthor | Doo-Jin Kim | - |
dc.contributor.googleauthor | Young-Kyoung You | - |
dc.contributor.googleauthor | Hee-Chul Yu | - |
dc.identifier.doi | 10.4240/wjgs.v15.i7.1340 | - |
dc.contributor.localId | A03948 | - |
dc.relation.journalcode | J04555 | - |
dc.identifier.eissn | 1948-9366 | - |
dc.identifier.pmid | 37555110 | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | Intrahepatic cholangiocarcinoma | - |
dc.subject.keyword | Liver transplantation | - |
dc.subject.keyword | Outcomes | - |
dc.subject.keyword | Recurrence | - |
dc.contributor.alternativeName | Joo, Dong Jin | - |
dc.contributor.affiliatedAuthor | 주동진 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1340 | - |
dc.citation.endPage | 1353 | - |
dc.identifier.bibliographicCitation | WORLD JOURNAL OF GASTROINTESTINAL SURGERY, Vol.15(7) : 1340-1353, 2023-07 | - |
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