Cited 4 times in
External Validation of the eCura System for Undifferentiated-Type Early Gastric Cancer with Noncurative Endoscopic Resection
DC Field | Value | Language |
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dc.contributor.author | 김지현 | - |
dc.contributor.author | 신성관 | - |
dc.date.accessioned | 2024-03-22T05:56:43Z | - |
dc.date.available | 2024-03-22T05:56:43Z | - |
dc.date.issued | 2023-07 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198303 | - |
dc.description.abstract | Background/Aims: The eCura system, a scoring model for stratifying the lymph node metastasis risk after noncurative endoscopic resection for early gastric cancer (EGC), has been internally validated, primarily for differentiated-type EGC. We aimed to externally validate this model for undifferentiated-type EGC. Methods: This multicenter, retrospective cohort study included 634 patients who underwent additional surgery (radical surgery group, n=270) or were followed up without additional treatment (no additional treatment group, n=364) after noncurative endoscopic resection for undifferentiated- type EGC between 2005 and 2015. The lymph node metastasis and survival rates were compared according to the risk categories. Results: For the radical surgery group, the lymph node metastasis rates were 2.6%, 10.9%, and 14.8% for the low-, intermediate-, and high-risk eCura categories, respectively (p for trend=0.003). For the low-, intermediate-, and high-risk categories in the no additional treatment group, the overall survival (92.7%, 68.9%, and 80.0% at 5 years, respectively, p<0.001) and cancer-specific survival rates (99.7%, 94.7%, and 80.0% at 5 years, respectively, p<0.001) differed significantly. In the multivariate analysis, the hazard ratios (95% confidence interval) in the no additional treatment group relative to the radical surgery group were 3.18 (1.41 to 7.17; p=0.005) for overall mortality and 2.60 (0.46 to 14.66; p=0.280) for cancer-specific mortality in the intermediate-tohigh risk category. No such differences were noted in the low-risk category. Conclusions: The eCura system can be applied to undifferentiated-type EGC. Close follow-up without additional treatment might be considered for low-risk patients, while additional surgery is recommended for intermediate- and high-risk patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Editorial Office of Gut and Liver | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Early Detection of Cancer | - |
dc.subject.MESH | Endoscopic Mucosal Resection* | - |
dc.subject.MESH | Gastrectomy | - |
dc.subject.MESH | Gastric Mucosa / pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Stomach Neoplasms* / pathology | - |
dc.subject.MESH | Stomach Neoplasms* / surgery | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | External Validation of the eCura System for Undifferentiated-Type Early Gastric Cancer with Noncurative Endoscopic Resection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyo-Joon Yang | - |
dc.contributor.googleauthor | Young-Il Kim | - |
dc.contributor.googleauthor | Ji Yong Ahn | - |
dc.contributor.googleauthor | Kee Don Choi | - |
dc.contributor.googleauthor | Sang Gyun Kim | - |
dc.contributor.googleauthor | Seong Woo Jeon | - |
dc.contributor.googleauthor | Jie-Hyun Kim | - |
dc.contributor.googleauthor | Sung Kwan Shin | - |
dc.contributor.googleauthor | Hyuk Lee | - |
dc.contributor.googleauthor | Wan Sik Lee | - |
dc.contributor.googleauthor | Gwang Ha Kim | - |
dc.contributor.googleauthor | Jae Myung Park | - |
dc.contributor.googleauthor | Woon Geon Shin | - |
dc.contributor.googleauthor | Il Ju Choi | - |
dc.identifier.doi | 10.5009/gnl220333 | - |
dc.contributor.localId | A00996 | - |
dc.relation.journalcode | J00954 | - |
dc.identifier.eissn | 2005-1212 | - |
dc.identifier.pmid | 37161698 | - |
dc.subject.keyword | Endoscopic mucosal resection | - |
dc.subject.keyword | Lymphatic metastasis | - |
dc.subject.keyword | Stomach neoplasms | - |
dc.subject.keyword | Undifferentiated-type histology | - |
dc.subject.keyword | Validation study | - |
dc.contributor.alternativeName | Kim, Jie-Hyun | - |
dc.contributor.affiliatedAuthor | 김지현 | - |
dc.citation.volume | 17 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 537 | - |
dc.citation.endPage | 546 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, Vol.17(4) : 537-546, 2023-07 | - |
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