Cited 0 times in
Exposure to Benzo[a]pyrene and 1-Nitropyrene in Particulate Matter Increases Oxidative Stress in the Human Body
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 원종욱 | - |
dc.date.accessioned | 2024-03-22T05:56:39Z | - |
dc.date.available | 2024-03-22T05:56:39Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198302 | - |
dc.description.abstract | Polycyclic aromatic hydrocarbons (PAHs) have been reported to cause oxidative stress in metabolic processes. This study aimed to evaluate the relationship between exposure to PAHs, including benzo[a]pyrene (BaP) and 1-nitropyrene (1-NP), in the atmosphere and oxidative stress levels in the human body. This study included 44 Korean adults who lived in Cheongju, Republic of Korea. Atmospheric BaP and 1-NP concentrations and urinary 6-hydroxy-1-nitropyrene (6-OHNP), N-acetyl-1-aminopyrene (1-NAAP), and 1-hydroxypyrene (1-OHP) concentrations were measured. The oxidative stress level was assessed by measuring urinary thiobarbituric acid-reactive substances (TBARS) and 8-hydroxydeoxyguanosine (8-OHdG) concentrations. Urinary TBARS and 6-OHNP concentrations significantly differed between winter and summer. BaP exposure was significantly associated with urinary 8-OHdG concentrations in summer. However, atmospheric 1-NP did not show a significant correlation with oxidative stress marker concentrations. Urinary 1-NAAP concentration was a significant determinant for urinary 8-OHdG concentration in summer. Oxidative stress in the body increases in proportion to inhalation exposure to BaP, and more 8-OHdG is produced in the body as the amount of 1-NP, which is metabolized to 1-AP or 1-NAAP, increases. © 2023 by the authors. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | TOXICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Exposure to Benzo[a]pyrene and 1-Nitropyrene in Particulate Matter Increases Oxidative Stress in the Human Body | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Occupational and Environmental Medicine (작업환경의학과) | - |
dc.contributor.googleauthor | Sun-Haeng Choi | - |
dc.contributor.googleauthor | Bolormaa Ochirpurev | - |
dc.contributor.googleauthor | Akira Toriba | - |
dc.contributor.googleauthor | Jong-Uk Won | - |
dc.contributor.googleauthor | Heon Kim | - |
dc.identifier.doi | 10.3390/toxics11090797 | - |
dc.contributor.localId | A02442 | - |
dc.relation.journalcode | J03975 | - |
dc.identifier.eissn | 2305-6304 | - |
dc.identifier.pmid | 37755807 | - |
dc.subject.keyword | 1-nitropyrene | - |
dc.subject.keyword | 8-hydroxydeoxyguanosine | - |
dc.subject.keyword | benzo[a]pyrene | - |
dc.subject.keyword | oxidative stress | - |
dc.subject.keyword | polycyclic aromatic hydrocarbons | - |
dc.subject.keyword | thiobarbituric acid-reactive substances | - |
dc.contributor.alternativeName | Won, Jong Uk | - |
dc.contributor.affiliatedAuthor | 원종욱 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 797 | - |
dc.identifier.bibliographicCitation | TOXICS, Vol.11(9) : 797, 2023-09 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.