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Effectiveness of low-intensity atorvastatin 5 mg and ezetimibe 10 mg combination therapy compared with moderate-intensity atorvastatin 10 mg monotherapy: A randomized, double-blinded, multi-center, phase III study
DC Field | Value | Language |
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dc.contributor.author | 김철식 | - |
dc.contributor.author | 이상학 | - |
dc.date.accessioned | 2024-03-22T05:53:37Z | - |
dc.date.available | 2024-03-22T05:53:37Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198276 | - |
dc.description.abstract | Background: We compared the efficacy and safety of low-intensity atorvastatin and ezetimibe combination therapy with moderate-intensity atorvastatin monotherapy in patients requiring cholesterol-lowering therapy. Methods: At 19 centers in Korea, 290 patients were randomized to 4 groups: atorvastatin 5 mg and ezetimibe 10 mg (A5E), ezetimibe 10 mg (E), atorvastatin 5 mg (A5), and atorvastatin 10 mg (A10). Clinical and laboratory examinations were performed at baseline, and at 4-week and 8-week follow-ups. The primary endpoint was percentage change from baseline in low-density lipoprotein (LDL) cholesterol levels at the 8-week follow-up. Secondary endpoints included percentage changes from baseline in additional lipid parameters. Results: Baseline characteristics were similar among the study groups. At the 8-week follow-up, percentage changes in LDL cholesterol levels were significantly greater in the A5E group (49.2%) than in the E (18.7%), A5 (27.9%), and A10 (36.4%) groups. Similar findings were observed regarding the percentage changes in total cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B levels. Triglyceride levels were also significantly decreased in the A5E group than in the E group, whereas high-density lipoprotein levels substantially increased in the A5E group than in the E group. In patients with low- and intermediate-cardiovascular risk, 93.3% achieved the target LDL cholesterol levels in the A5E group, 40.0% in the E group, 66.7% in the A5 group, and 92.9% in the A10 group. In addition, 31.4% of patients in the A5E group, 8.1% in E, 9.7% in A5, and 7.3% in the A10 group reached the target levels of both LDL cholesterol < 70 mg/dL and reduction of LDL ≥ 50% from baseline. Conclusions: The addition of ezetimibe to low-intensity atorvastatin had a greater effect on lowering LDL cholesterol than moderate-intensity atorvastatin alone, offering an effective treatment option for cholesterol management, especially in patients with low and intermediate risks. © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anticholesteremic Agents* / therapeutic use | - |
dc.subject.MESH | Atorvastatin / therapeutic use | - |
dc.subject.MESH | Azetidines* / therapeutic use | - |
dc.subject.MESH | Cholesterol | - |
dc.subject.MESH | Cholesterol, LDL | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Ezetimibe / therapeutic use | - |
dc.subject.MESH | Heptanoic Acids* / adverse effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors* / therapeutic use | - |
dc.subject.MESH | Hypercholesterolemia* / drug therapy | - |
dc.subject.MESH | Pyrroles / therapeutic use | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Effectiveness of low-intensity atorvastatin 5 mg and ezetimibe 10 mg combination therapy compared with moderate-intensity atorvastatin 10 mg monotherapy: A randomized, double-blinded, multi-center, phase III study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seung-Ah Lee | - |
dc.contributor.googleauthor | Soon Jun Hong | - |
dc.contributor.googleauthor | Jung-Hoon Sung | - |
dc.contributor.googleauthor | Kyung-Soo Kim | - |
dc.contributor.googleauthor | Seong Hwan Kim | - |
dc.contributor.googleauthor | Jin Man Cho | - |
dc.contributor.googleauthor | Sung Wan Chun | - |
dc.contributor.googleauthor | Sang Rok Lee | - |
dc.contributor.googleauthor | Chul Sik Kim | - |
dc.contributor.googleauthor | Tae Nyun Kim | - |
dc.contributor.googleauthor | Dae Hyeok Kim | - |
dc.contributor.googleauthor | Hwan-Cheol Park | - |
dc.contributor.googleauthor | Byung Jin Kim | - |
dc.contributor.googleauthor | Hyun-Sook Kim | - |
dc.contributor.googleauthor | Ji-Yong Choi | - |
dc.contributor.googleauthor | Young Joon Hong | - |
dc.contributor.googleauthor | Joong Wha Chung | - |
dc.contributor.googleauthor | Seong Bo Yoon | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Cheol Whan Lee | - |
dc.identifier.doi | 10.1097/MD.0000000000036122 | - |
dc.contributor.localId | A01054 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 38013289 | - |
dc.contributor.alternativeName | Kim, Chul Sik | - |
dc.contributor.affiliatedAuthor | 김철식 | - |
dc.citation.volume | 102 | - |
dc.citation.number | 47 | - |
dc.citation.startPage | e36122 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.102(47) : e36122, 2023-11 | - |
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