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Early Aortic Valve Replacement in Symptomatic Normal-Flow, Low-Gradient Severe Aortic Stenosis: A Propensity Score-Matched Retrospective Cohort Study
DC Field | Value | Language |
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dc.contributor.author | 고규용 | - |
dc.contributor.author | 심지영 | - |
dc.contributor.author | 이삭 | - |
dc.contributor.author | 이승현 | - |
dc.contributor.author | 조익성 | - |
dc.contributor.author | 하종원 | - |
dc.contributor.author | 홍그루 | - |
dc.contributor.author | 김규 | - |
dc.date.accessioned | 2024-03-22T05:52:25Z | - |
dc.date.available | 2024-03-22T05:52:25Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198268 | - |
dc.description.abstract | Background and Objectives: Aortic valve replacement (AVR) is considered a class I indication for symptomatic severe aortic stenosis (AS). However, there is little evidence regarding the potential benefits of early AVR in symptomatic patients diagnosed with normal-flow, low-gradient (NFLG) severe AS. Methods: Two-hundred eighty-one patients diagnosed with symptomatic NFLG severe AS (stroke volume index ≥35 mL/m2, mean transaortic pressure gradient <40 mmHg, peak transaortic velocity <4 m/s, and aortic valve area <1.0 cm2) between January 2010 and December 2020 were included in this retrospective study. After performing 1:1 propensity score matching, 121 patients aged 75.1±9.8 years (including 63 women) who underwent early AVR within 3 months after index echocardiography, were compared with 121 patients who received conservative care. The primary outcome was a composite of all-cause death and heart failure (HF) hospitalization. Results: During a median follow-up of 21.9 months, 48 primary outcomes (18 in the early AVR group and 30 in the conservative care group) occurred. The early AVR group demonstrated a significantly lower incidence of primary outcomes (hazard ratio [HR], 0.52; 95% confidence interval [CI], 0.29–0.93; p=0.028); specifically, there was no significant difference in all-cause death (HR, 0.51; 95% CI, 0.23–1.16; p=0.110), although the early AVR group showed a significantly lower incidence of hospitalization for HF (HR, 0.43; 95% CI, 0.19–0.95, p=0.037). Subgroup analyses supported the main findings. Conclusions: An early AVR strategy may be beneficial in reducing the risk of a composite outcome of death or hospitalization for HF in symptomatic patients with NFLG severe AS. Future randomized studies are required to validate and confirm our findings. © 2023 Korean Society of Circulation. All rights reserved. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society of Circulation | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Early Aortic Valve Replacement in Symptomatic Normal-Flow, Low-Gradient Severe Aortic Stenosis: A Propensity Score-Matched Retrospective Cohort Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kyu Kim | - |
dc.contributor.googleauthor | Iksung Cho | - |
dc.contributor.googleauthor | Kyu-Yong Ko | - |
dc.contributor.googleauthor | Seung-Hyun Lee | - |
dc.contributor.googleauthor | Sak Lee | - |
dc.contributor.googleauthor | Geu-Ru Hong | - |
dc.contributor.googleauthor | Jong-Won Ha | - |
dc.contributor.googleauthor | Chi Young Shim | - |
dc.identifier.doi | 10.4070/kcj.2023.0022 | - |
dc.contributor.localId | A06274 | - |
dc.contributor.localId | A02213 | - |
dc.contributor.localId | A02807 | - |
dc.contributor.localId | A02935 | - |
dc.contributor.localId | A03888 | - |
dc.contributor.localId | A04257 | - |
dc.contributor.localId | A04386 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.identifier.pmid | 37653715 | - |
dc.subject.keyword | Aortic valve stenosis | - |
dc.subject.keyword | Heart failure | - |
dc.subject.keyword | Mortality | - |
dc.subject.keyword | Surgical valves | - |
dc.subject.keyword | Transcatheter aortic valve replacement | - |
dc.contributor.alternativeName | Go, Kyu-Yong | - |
dc.contributor.affiliatedAuthor | 고규용 | - |
dc.contributor.affiliatedAuthor | 심지영 | - |
dc.contributor.affiliatedAuthor | 이삭 | - |
dc.contributor.affiliatedAuthor | 이승현 | - |
dc.contributor.affiliatedAuthor | 조익성 | - |
dc.contributor.affiliatedAuthor | 하종원 | - |
dc.contributor.affiliatedAuthor | 홍그루 | - |
dc.citation.volume | 53 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 744 | - |
dc.citation.endPage | 755 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.53(11) : 744-755, 2023-11 | - |
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