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Comparing the Efficacy of Carvedilol and Flecainide on the Treatment of Idiopathic Premature Ventricular Complexes from Ventricular Outflow Tract: A Multicenter, Randomized, Open-Label Pilot Study
DC Field | Value | Language |
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dc.contributor.author | 김태훈 | - |
dc.date.accessioned | 2024-03-22T05:49:23Z | - |
dc.date.available | 2024-03-22T05:49:23Z | - |
dc.date.issued | 2023-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198228 | - |
dc.description.abstract | The mechanism of premature ventricular complexes (PVC) occurring in the ventricular outflow tract (OT) is related to an intracellular calcium overload and delayed afterdepolarizations that lead to triggered activity. The guidelines recommend using beta-blockers and flecainide for idiopathic PVCs, but they also acknowledge the limited evidence supporting this recommendation. We conducted a multicenter, randomized, open-label pilot study comparing the effect of carvedilol and flecainide on OT PVC, which are widely used to treat this arrhythmia. Patients with a 24 h Holter recording a PVC burden ≥ 5%, which showed positive R waves in leads II, III, and aVF, and without structural heart disease were enrolled. They were randomly assigned to the carvedilol or flecainide group, and the maximum tolerated dose was administered for 12 weeks. A total of 103 participants completed the protocol: 51 with carvedilol and 52 with flecainide. After 12 weeks of treatment, the mean PVC burden significantly decreased in both groups: 20.3 ± 11.5 to 14.6 ± 10.8% with carvedilol (p < 0.0001) and 17.1 ± 9.9 to 6.6 ± 9.9% with flecainide (p < 0.0001). Both carvedilol and flecainide effectively suppressed OT PVCs in patients without structural heart disease, with flecainide showing a superior efficacy compared to carvedilol. © 2023 by the authors. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Comparing the Efficacy of Carvedilol and Flecainide on the Treatment of Idiopathic Premature Ventricular Complexes from Ventricular Outflow Tract: A Multicenter, Randomized, Open-Label Pilot Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jongmin Hwang | - |
dc.contributor.googleauthor | Yong-Seog Oh | - |
dc.contributor.googleauthor | Hyoung-Seob Park | - |
dc.contributor.googleauthor | Jong-Il Choi | - |
dc.contributor.googleauthor | Young Soo Lee | - |
dc.contributor.googleauthor | Eue-Keun Choi | - |
dc.contributor.googleauthor | Dong-Gu Shin | - |
dc.contributor.googleauthor | Young Keun On | - |
dc.contributor.googleauthor | Tae-Hoon Kim 8 | - |
dc.contributor.googleauthor | Hyung Wook Park | - |
dc.contributor.googleauthor | Min Soo Cho | - |
dc.contributor.googleauthor | Myung Hwan Bae | - |
dc.contributor.googleauthor | Seongwook Han | - |
dc.identifier.doi | 10.3390/jcm12082887 | - |
dc.contributor.localId | A01085 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 37109225 | - |
dc.subject.keyword | anti-arrhythmia agents | - |
dc.subject.keyword | carvedilol | - |
dc.subject.keyword | ventricular premature complexes | - |
dc.contributor.alternativeName | Kim, Tae-Hoon | - |
dc.contributor.affiliatedAuthor | 김태훈 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2887 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.12(8) : 2887, 2023-04 | - |
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