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Antigen-independent IL-17A production by bystander-activated CD4+IL-1R1+ cells in patients with multiple sclerosis
DC Field | Value | Language |
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dc.contributor.author | 이은직 | - |
dc.date.accessioned | 2024-03-22T05:44:25Z | - |
dc.date.available | 2024-03-22T05:44:25Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 0198-8859 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198177 | - |
dc.description.abstract | Multiple sclerosis (MS) is a demyelinating disease caused by auto-antigen recognizing CD4+ T cells. However, IL-17A-producing CD4+ T cells that are bystander-activated by IL-1β and IL-23, and T cell receptors independently, could contribute to experimental autoimmune encephalomyelitis. Here, we studied the differences in the frequency and function of bystander-activated CD4+ T cells in patients with MS. A significantly higher frequency of CD4 + IL-1Rl + T cells was found in memory than in naïve CD4+ T cells and in Th17/Th17.1 than in Th1/Th2 subtypes in both MS and healthy controls (HC). Following IL-1β and IL-23 stimulation, IL-1Rl expression was markedly increased in both memory and Th17/Th17.1 cells, and their IL-17A-production was increased after bystander-activation, which was significantly higher in MS compared with HC. Our study suggests a potential role of IL-17A-producing bystander-activated CD4+IL-1Rl+ T cells in MS. © 2022 American Society for Histocompatibility and Immunogenetics | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier/North-Holland | - |
dc.relation.isPartOf | HUMAN IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | CD4-Positive T-Lymphocytes* | - |
dc.subject.MESH | Encephalomyelitis, Autoimmune, Experimental | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-17* / metabolism | - |
dc.subject.MESH | Interleukin-23 / metabolism | - |
dc.subject.MESH | Multiple Sclerosis* / metabolism | - |
dc.subject.MESH | Th17 Cells | - |
dc.title | Antigen-independent IL-17A production by bystander-activated CD4+IL-1R1+ cells in patients with multiple sclerosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.contributor.googleauthor | Yeseul Kim | - |
dc.contributor.googleauthor | Su-Hyun Kim | - |
dc.contributor.googleauthor | Sang-Min Han | - |
dc.contributor.googleauthor | Hyewon Park | - |
dc.contributor.googleauthor | Rosah May Payumo | - |
dc.contributor.googleauthor | Ha Eun Kim | - |
dc.contributor.googleauthor | Jae-Won Hyun | - |
dc.contributor.googleauthor | Ki Hoon Kim | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.contributor.googleauthor | Ho Jin Kim | - |
dc.identifier.doi | 10.1016/j.humimm.2022.12.004 | - |
dc.contributor.localId | A03050 | - |
dc.relation.journalcode | J02870 | - |
dc.identifier.eissn | 1879-1166 | - |
dc.identifier.pmid | 36609052 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0198885922002531 | - |
dc.subject.keyword | Bystander-activation | - |
dc.subject.keyword | IL-17A | - |
dc.subject.keyword | Multiple sclerosis | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | 이은직 | - |
dc.citation.volume | 84 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 241 | - |
dc.citation.endPage | 246 | - |
dc.identifier.bibliographicCitation | HUMAN IMMUNOLOGY, Vol.84(3) : 241-246, 2023-03 | - |
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