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Bladder Preservation With Transurethral Tumor Resection and Intravesical BCG Instillation in Superficial Muscle-Invasive Bladder Cancer: A 13-Year Follow-up
DC Field | Value | Language |
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dc.contributor.author | 이종수 | - |
dc.contributor.author | 장원식 | - |
dc.contributor.author | 조강수 | - |
dc.contributor.author | 조남훈 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 허지은 | - |
dc.date.accessioned | 2024-02-15T06:51:47Z | - |
dc.date.available | 2024-02-15T06:51:47Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 2951-603X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198064 | - |
dc.description.abstract | Purpose: The aim of this study was to evaluate the 10-year oncological outcomes of bladder preservation with transurethral resection of bladder tumor (TURBT) and intravesical bacillus Calmette-Guérin (BCG) instillation in selected patients with superficial muscle-invasive bladder cancer (MIBC). Materials and Methods: Patients diagnosed with superficial MIBC (stage T2a) by TURBT between 2001 and 2009 were included. Cystectomy-free survival, recurrence-free survival (RFS), progression-free survival (PFS), and cancer-specific survival (CSS) were estimated using the Kaplan-Meier method. Cox regression analysis was used to identify predictors of each type of survival. Results: Of 145 patients, 135 underwent bladder preservation and 10 underwent immediate radical cystectomy (RC). Among the latter, 9 patients showed downstaging. During a median follow-up of 132 months (interquartile range, 96–161 months), 13 patients underwent RC, with a 10-year cystectomy-free survival rate of 83.9%. Seventy patients (48.3%) had recurrence, and the 10-year RFS rate was 48.9%. Progression occurred in 12 patients (8.3%), with a 10-year PFS rate of 90.1%. Death occurred only in patients who exhibited progression; 5 patients (3.4%) died of bladder cancer, and the 10-year CSS rate was 96.5%. Tumors greater than 3 cm were associated with RC, and a high tumor grade predicted recurrence. RC was related to progression and cancer specific mortality. Conclusions: Although high-grade tumors require careful follow-up, bladder preservation with TURBT and intravesical BCG instillation can enable the successful management of selected patients with stage T2a MIBC less than 3 cm, without carcinoma in situ or tumor-associated hydronephrosis, in a nonmetastatic setting. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Urological Oncology Society | - |
dc.relation.isPartOf | Journal of Urologic Oncology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Bladder Preservation With Transurethral Tumor Resection and Intravesical BCG Instillation in Superficial Muscle-Invasive Bladder Cancer: A 13-Year Follow-up | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Dong Gyun Kim | - |
dc.contributor.googleauthor | Ji Eun Heo | - |
dc.contributor.googleauthor | Kang Su Cho | - |
dc.contributor.googleauthor | Jongsoo Lee | - |
dc.contributor.googleauthor | Won Sik Jang | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.identifier.doi | 10.22465/juo.224400380019 | - |
dc.contributor.localId | A05500 | - |
dc.contributor.localId | A05268 | - |
dc.contributor.localId | A03801 | - |
dc.contributor.localId | A03812 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A05531 | - |
dc.relation.journalcode | J04524 | - |
dc.identifier.eissn | 2982-7043 | - |
dc.contributor.alternativeName | Lee, Jong Soo | - |
dc.contributor.affiliatedAuthor | 이종수 | - |
dc.contributor.affiliatedAuthor | 장원식 | - |
dc.contributor.affiliatedAuthor | 조강수 | - |
dc.contributor.affiliatedAuthor | 조남훈 | - |
dc.contributor.affiliatedAuthor | 최영득 | - |
dc.contributor.affiliatedAuthor | 허지은 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 70 | - |
dc.citation.endPage | 78 | - |
dc.identifier.bibliographicCitation | Journal of Urologic Oncology, Vol.21(1) : 70-78, 2023-03 | - |
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