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Incidence, Morbidity, and Mortality of Achalasia: A Nationwide, Population-Based Cohort Study in South Korea
DC Field | Value | Language |
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dc.contributor.author | 김가희 | - |
dc.date.accessioned | 2024-02-15T06:45:14Z | - |
dc.date.available | 2024-02-15T06:45:14Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198018 | - |
dc.description.abstract | Background/aims: Although an association between achalasia and esophageal cancer has been reported, whether achalasia confers a substantial increase in mortality is unknown. Moreover, the causes of death related to achalasia have not been investigated. We performed this nationwide, population-based cohort study on achalasia because no such study has been performed since the introduction of high-resolution manometry in 2008. Methods: This study was performed using data extracted from the Korean National Health Insurance Service database, covering a 9-year period from 2009 to 2017. Control participants without a diagnostic code for achalasia were randomly selected and matched by sex and birth year at a case-to-control ratio of 1:4. Data on the cause of death from Statistics Korea were also analyzed. Results: The overall incidence of achalasia was 0.68 per 100,000 person-years, and the prevalence was 6.46 per 100,000 population. Patients with achalasia (n=3,063) had significantly higher adjusted hazard ratio (aHR) for esophageal cancer (aHR, 3.40; 95% confidence interval [CI], 1.25 to 9.22; p=0.017), pneumonia (aHR, 2.30; 95% CI, 1.89 to 2.81; p<0.001), aspiration pneumonia (aHR, 3.92; 95% CI, 2.38 to 6.48; p<0.001), and mortality (aHR, 1.68; 95% CI, 1.44 to 1.94; p<0.001). Esophageal cancer carried the highest mortality risk (aHR, 8.82; 95% CI, 2.35 to 33.16; p=0.001), while pneumonia had the highest non-cancer mortality risk (aHR, 2.28; 95% CI, 1.31 to 3.96; p=0.004). Conclusions: In this nationwide study, achalasia was associated with increased risk of mortality. Esophageal cancer and pneumonia were the most common comorbidities and the major causes of death in patients with achalasia. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Editorial Office of Gut and Liver | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Esophageal Achalasia* / epidemiology | - |
dc.subject.MESH | Esophageal Neoplasms* / epidemiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Morbidity | - |
dc.subject.MESH | Pneumonia* / complications | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Incidence, Morbidity, and Mortality of Achalasia: A Nationwide, Population-Based Cohort Study in South Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ga Hee Kim | - |
dc.contributor.googleauthor | Hyungchul Park | - |
dc.contributor.googleauthor | Kee Wook Jung | - |
dc.contributor.googleauthor | Min-Ju Kim | - |
dc.contributor.googleauthor | Ye-Jee Kim | - |
dc.contributor.googleauthor | Ji Min Lee | - |
dc.contributor.googleauthor | Bong Eun Lee | - |
dc.contributor.googleauthor | Yang Won Min | - |
dc.contributor.googleauthor | Jeong Hwan Kim | - |
dc.contributor.googleauthor | Hee Kyong Na | - |
dc.contributor.googleauthor | Ji Yong Ahn | - |
dc.contributor.googleauthor | Jeong Hoon Lee | - |
dc.contributor.googleauthor | Do Hoon Kim | - |
dc.contributor.googleauthor | Kee Don Choi | - |
dc.contributor.googleauthor | Ho June Song | - |
dc.contributor.googleauthor | Gin Hyug Lee | - |
dc.contributor.googleauthor | Hwoon-Yong Jung | - |
dc.contributor.googleauthor | Hyun Jin Kim | - |
dc.contributor.googleauthor | Big Data Study Group Under the Korean Society of Neurogastroenterology and Motility | - |
dc.identifier.doi | 10.5009/gnl220334. | - |
dc.contributor.localId | A06526 | - |
dc.relation.journalcode | J00954 | - |
dc.identifier.eissn | 2005-1212 | - |
dc.identifier.pmid | 36987382 | - |
dc.subject.keyword | Aspiration pneumonia | - |
dc.subject.keyword | Esophageal achalasia | - |
dc.subject.keyword | Esophageal neoplasms | - |
dc.subject.keyword | Esophagus | - |
dc.contributor.alternativeName | Kim, Ga Hee | - |
dc.contributor.affiliatedAuthor | 김가희 | - |
dc.citation.volume | 17 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 894 | - |
dc.citation.endPage | 904 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, Vol.17(6) : 894-904, 2023-11 | - |
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