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Effect of cholesterol variability on the incidence of cataract, dementia, and osteoporosis: A study using a common data model

 Jong Sung Park  ;  Do-Hoon Kim  ;  Byong-Kyu Kim  ;  Kyeong-Hyeon Park  ;  Dong Ho Park  ;  Yang Ha Hwang  ;  Chang-Yeon Kim 
 MEDICINE, Vol.102(41) : e35548, 2023-10 
Journal Title
Issue Date
Cardiovascular Diseases* / epidemiology ; Cataract* / epidemiology ; Cholesterol ; Cholesterol, HDL ; Dementia* / epidemiology ; Humans ; Incidence ; Osteoporosis* / epidemiology ; Triglycerides
The effects of cholesterol variability on cataracts, dementia, and osteoporosis remain controversial. Using a common data model, we investigated the effects of variations in cholesterol levels on the development of cataracts, dementia, and osteoporosis. Patients who received statin therapy between 2011 and 2020 and those with 3 or more tests for total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) levels were included. The patients were divided into those with a coefficient of variation (CV) of TC higher than the mean (high-CV group) and those with a lower CV of TC (low-CV group). Moreover, 1:1 propensity score matching was conducted based on demographic variables. Cataract, dementia, or osteoporosis was defined as having a diagnostic, drug, or surgical code based on the cohort definition. Of the 12,882 patients, cataracts, dementia, and osteoporosis were developed in 525 (4.1%), 198 (1.5%), and 438 (3.4%) patients, respectively. The stratified Cox proportional hazards model showed that the incidences of cataracts and osteoporosis were 1.38 and 1.45 times greater in the high-CV group than in the low-CV group, respectively. Our study revealed that TC variability is associated with developing cataracts and osteoporosis. Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
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1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyeong-Hyeon(박경현) ORCID logo https://orcid.org/0000-0001-7215-6176
Park, Jong Seoung(박종성)
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