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Impact of High-Intensity Statin on Early Neurologic Deterioration in Patients with Single Small Subcortical Infarction
DC Field | Value | Language |
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dc.contributor.author | 유준상 | - |
dc.date.accessioned | 2024-02-15T06:40:09Z | - |
dc.date.available | 2024-02-15T06:40:09Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197986 | - |
dc.description.abstract | Backgrounds: One of the major hypotheses for early neurological deterioration (END) in single small subcortical infarction (SSSI) is the process of atherosclerosis. However, the association between statin therapy, especially high-intensity statin therapy, and its effectiveness in reducing the incidence of END during the acute phase of SSSI remains unclear. This study aimed to investigate the influence of high-intensity statin therapy compared to moderate-intensity statin therapy during the acute phase on the incidence of END in SSSI. Methods: The records of 492 patients with SSSI who received statin therapy within 72 h of symptom onset from a prospective stroke registry were analyzed. The association between END and statin intensity was evaluated using multivariable regression analysis for adjusted odds ratio (aOR). Results: Of the 492 patients with SSSI (mean age: 67.2 years, median NIHSS score on admission: 3), END occurred in 102 (20.7%). Older age (aOR, 1.02; 95% confidence interval (CI), 1.00–1.05; p = 0.017), and branch atheromatous lesion (aOR, 3.49; 95% CI 2.16–5.74; p < 0.001) were associated with END. Early high-intensity statin therapy was associated with a lower incidence of END than moderate-intensity statin therapy (aOR, 0.44; 95% CI, 0.25–0.77; p = 0.004). In addition, there was significantly lower incidence of END in early administration (≤24 h) of high-intensity statin group. Conclusions: We identified an association between the intensity of early statin therapy and END in patients with SSSI. Early administration of high-intensity statin (≤24 h) is associated with a reduced incidence of END in patients with SSSI. © 2023 by the authors. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Impact of High-Intensity Statin on Early Neurologic Deterioration in Patients with Single Small Subcortical Infarction | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Seong Hwa Jang | - |
dc.contributor.googleauthor | Hyungjong Park | - |
dc.contributor.googleauthor | Jeong-Ho Hong | - |
dc.contributor.googleauthor | Joonsang Yoo | - |
dc.contributor.googleauthor | Hyung Lee | - |
dc.contributor.googleauthor | Hyun Ah Kim | - |
dc.contributor.googleauthor | Sung-Il Sohn | - |
dc.identifier.doi | 10.3390/jcm12093260 | - |
dc.contributor.localId | A02513 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 37176701 | - |
dc.subject.keyword | atherosclerosis | - |
dc.subject.keyword | early neurologic deterioration | - |
dc.subject.keyword | ischemic stroke | - |
dc.subject.keyword | single small subcortical infarction | - |
dc.subject.keyword | statin | - |
dc.contributor.alternativeName | Yoo, Joon Sang | - |
dc.contributor.affiliatedAuthor | 유준상 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 3260 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.12(9) : 3260, 2023-05 | - |
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