36 116

Cited 0 times in

Comparison of the effect of gonadotropin-releasing hormone agonist dosage in girls with central precocious puberty

DC Field Value Language
dc.contributor.author권아름-
dc.contributor.author김호성-
dc.contributor.author서정환-
dc.contributor.author송경철-
dc.contributor.author채현욱-
dc.contributor.author장신영-
dc.contributor.author김수진-
dc.contributor.author이명섭-
dc.date.accessioned2024-01-31T05:46:33Z-
dc.date.available2024-01-31T05:46:33Z-
dc.date.issued2023-12-
dc.identifier.issn2287-1012-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/197895-
dc.description.abstractPurpose: There are no definite guidelines on the optimal dosage of gonadotropin-releasing hormone (GnRH) agonist for treatment of central precocious puberty (CPP). We compared growth outcomes of GnRH agonist at different dosages in girls with idiopathic CPP to assess the optimal dosage. Methods: This retrospective study included 86 girls with idiopathic CPP who had been treated with GnRH agonist for at least one year and had attained their final adult height. Leuprolide was given as fixed dosage (3.75 mg every 4 weeks in body weight >20 kg, n=72) or weight-based dosage (60–85 μg/kg every 4 weeks, n=14). We compared suppression of advanced puberty and treatment response between the 2 groups. Results: Peak estradiol and luteinizing hormone and bone age (BA)/chronological age after injection of GnRH agonist were effectively suppressed in both groups. In both groups, the height standard deviation score (SDS) for BA increased after treatment. Final adult height (FAH) (fixed dosage group,160.8±4.1 cm and weight-based dosage group, 161.2±4.4 cm) was significantly higher than the initial predicted adult height (PAH) (155.5±3.3 and 156.1±3.6 cm, respectively) (both P<0.001) and similar to midparental height (159.8±3.3 and 160.6±3.7 cm, respectively). There were no differences in gain in height SDS for BA and gain in height (FAH-PAH at the start) between the 2 groups. Conclusion: There were no differences in treatment outcome between fixed dosage (3.75 mg/4 wk) and weight-based dosage (60–85 μg/kg/4wk) of GnRH agonist. Therefore, a fixed dosage of GnRH agonist can be used more conveniently for CPP treatment without growth oversuppression.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society of Pediatric Endocrinology-
dc.relation.isPartOfANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleComparison of the effect of gonadotropin-releasing hormone agonist dosage in girls with central precocious puberty-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학교실)-
dc.contributor.googleauthorShinyoung Jang-
dc.contributor.googleauthorSu Jin Kim-
dc.contributor.googleauthorMyeongseob Lee-
dc.contributor.googleauthorHae In Lee-
dc.contributor.googleauthorAhreum Kwon-
dc.contributor.googleauthorJunghwan Suh-
dc.contributor.googleauthorKyungchul Song-
dc.contributor.googleauthorHyun Wook Chae-
dc.contributor.googleauthorHo-Seong Kim-
dc.identifier.doi10.6065/apem.2244210.105-
dc.contributor.localIdA00228-
dc.contributor.localIdA01184-
dc.contributor.localIdA05629-
dc.contributor.localIdA06013-
dc.contributor.localIdA04026-
dc.relation.journalcodeJ00175-
dc.identifier.eissn2287-1292-
dc.identifier.pmid36758971-
dc.subject.keywordAdministration and dosage-
dc.subject.keywordGonadotropin-releasing hormone agonist-
dc.subject.keywordPrecocious puberty-
dc.subject.keywordTreatment outcome-
dc.contributor.alternativeNameKwon, Ah Reum-
dc.contributor.affiliatedAuthor권아름-
dc.contributor.affiliatedAuthor김호성-
dc.contributor.affiliatedAuthor서정환-
dc.contributor.affiliatedAuthor송경철-
dc.contributor.affiliatedAuthor채현욱-
dc.citation.volume28-
dc.citation.number4-
dc.citation.startPage283-
dc.citation.endPage288-
dc.identifier.bibliographicCitationANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, Vol.28(4) : 283-288, 2023-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.