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Increased Risk of Hip Fracture in Patients with Acromegaly: A Nationwide Cohort Study in Korea
DC Field | Value | Language |
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dc.contributor.author | 구철룡 | - |
dc.contributor.author | 김의현 | - |
dc.contributor.author | 문주형 | - |
dc.contributor.author | 이은직 | - |
dc.contributor.author | 홍남기 | - |
dc.contributor.author | 김지원 | - |
dc.date.accessioned | 2024-01-31T05:43:38Z | - |
dc.date.available | 2024-01-31T05:43:38Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197864 | - |
dc.description.abstract | Background: Acromegaly leads to various skeletal complications, and fragility fractures are emerging as a new concern in patients with acromegaly. Therefore, this study investigated the risk of fractures in Korean patients with acromegaly. Methods: We used the Korean nationwide claims database from 2009 to 2019. A total of 931 patients with acromegaly who had never used an osteoporosis drug before and were treated with surgery alone were selected as study participants, and a 1:29 ratio of 26,999 age- and sex-matched osteoporosis drug-naïve controls without acromegaly were randomly selected from the database. Results: The mean age was 46.2 years, and 50.0% were male. During a median follow-up of 54.1 months, there was no difference in the risks of all, vertebral, and non-vertebral fractures between the acromegaly and control groups. However, hip fracture risk was significantly higher (hazard ratio [HR], 2.73; 95% confidence interval [CI], 1.32 to 5.65), and non-hip and non-vertebral fractures risk was significantly lower (HR, 0.40; 95% CI, 0.17 to 0.98) in patients with acromegaly than in controls; these results remained robust even after adjustment for socioeconomic status and baseline comorbidities. Age, type 2 diabetes mellitus, cardio-cerebrovascular disease, fracture history, recent use of acid-suppressant medication, psychotropic medication, and opioids were risk factors for all fractures in patients with acromegaly (all P<0.05). Conclusion: Compared with controls, patients surgically treated for acromegaly had a higher risk of hip fractures. The risk factors for fracture in patients with acromegaly were consistent with widely accepted risk factors in the general population. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Endocrine Society | - |
dc.relation.isPartOf | Endocrinology and Metabolism(대한내분비학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Increased Risk of Hip Fracture in Patients with Acromegaly: A Nationwide Cohort Study in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jiwon Kim | - |
dc.contributor.googleauthor | Namki Hong | - |
dc.contributor.googleauthor | Jimi Choi | - |
dc.contributor.googleauthor | Ju Hyung Moon | - |
dc.contributor.googleauthor | Eui Hyun Kim | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.contributor.googleauthor | Sin Gon Kim | - |
dc.contributor.googleauthor | Cheol Ryong Ku | - |
dc.identifier.doi | 10.3803/EnM.2023.1782 | - |
dc.contributor.localId | A00201 | - |
dc.contributor.localId | A00837 | - |
dc.contributor.localId | A01383 | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A04388 | - |
dc.relation.journalcode | J00773 | - |
dc.identifier.eissn | 2093-5978 | - |
dc.identifier.pmid | 37899569 | - |
dc.subject.keyword | Acromegaly | - |
dc.subject.keyword | Hip fractures | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | Nationwide | - |
dc.contributor.alternativeName | Ku, Cheol Ryong | - |
dc.contributor.affiliatedAuthor | 구철룡 | - |
dc.contributor.affiliatedAuthor | 김의현 | - |
dc.contributor.affiliatedAuthor | 문주형 | - |
dc.contributor.affiliatedAuthor | 이은직 | - |
dc.contributor.affiliatedAuthor | 홍남기 | - |
dc.citation.volume | 38 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 690 | - |
dc.citation.endPage | 700 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism(대한내분비학회지), Vol.38(6) : 690-700, 2023-12 | - |
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