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Optimal planning target margin for prostate radiotherapy based on interfractional and intrafractional variability assessment during 1.5T MRI-guided radiotherapy
DC Field | Value | Language |
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dc.contributor.author | 김준원 | - |
dc.contributor.author | 김지훈 | - |
dc.contributor.author | 정병하 | - |
dc.contributor.author | 조강수 | - |
dc.contributor.author | 김진아 | - |
dc.contributor.author | 성지원 | - |
dc.date.accessioned | 2024-01-16T02:00:57Z | - |
dc.date.available | 2024-01-16T02:00:57Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197825 | - |
dc.description.abstract | Introduction: We analyzed daily pre-treatment- (PRE) and real-time motion monitoring- (MM) MRI scans of patients receiving definitive prostate radiotherapy (RT) with 1.5 T MRI guidance to assess interfractional and intrafractional variability of the prostate and suggest optimal planning target volume (PTV) margin. Materials and methods: Rigid registration between PRE-MRI and planning CT images based on the pelvic bone and prostate anatomy were performed. Interfractional setup margin (SM) and interobserver variability (IO) were assessed by comparing the centroid values of prostate contours delineated on PRE-MRIs. MM-MRIs were used for internal margin (IM) assessment, and PTV margin was calculated using the van Herk formula. Results: We delineated 400 prostate contours on PRE-MRI images. SM was 0.57 ± 0.42, 2.45 ± 1.98, and 2.28 ± 2.08 mm in the left-right (LR), anterior-posterior (AP), and superior-inferior (SI) directions, respectively, after bone localization and 0.76 ± 0.57, 1.89 ± 1.60, and 2.02 ± 1.79 mm in the LR, AP, and SI directions, respectively, after prostate localization. IO was 1.06 ± 0.58, 2.32 ± 1.08, and 3.30 ± 1.85 mm in the LR, AP, and SI directions, respectively, after bone localization and 1.11 ± 0.55, 2.13 ± 1.07, and 3.53 ± 1.65 mm in the LR, AP, and SI directions, respectively, after prostate localization. Average IM was 2.12 ± 0.86, 2.24 ± 1.07, and 2.84 ± 0.88 mm in the LR, AP, and SI directions, respectively. Calculated PTV margin was 2.21, 5.16, and 5.40 mm in the LR, AP, and SI directions, respectively. Conclusions: Movements in the SI direction were the largest source of variability in definitive prostate RT, and interobserver variability was a non-negligible source of margin. The optimal PTV margin should also consider the internal margin. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Optimal planning target margin for prostate radiotherapy based on interfractional and intrafractional variability assessment during 1.5T MRI-guided radiotherapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Jina Kim | - |
dc.contributor.googleauthor | Jiwon Sung | - |
dc.contributor.googleauthor | Seo Jin Lee | - |
dc.contributor.googleauthor | Kang Su Cho | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Dongjoon Yang | - |
dc.contributor.googleauthor | Jihun Kim | - |
dc.contributor.googleauthor | Jun Won Kim | - |
dc.identifier.doi | 10.3389/fonc.2023.1337626 | - |
dc.contributor.localId | A00958 | - |
dc.contributor.localId | A05823 | - |
dc.contributor.localId | A03607 | - |
dc.contributor.localId | A03801 | - |
dc.relation.journalcode | J03512 | - |
dc.identifier.eissn | 2234-943X | - |
dc.identifier.pmid | 38173837 | - |
dc.subject.keyword | MRI-guided radiotherapy | - |
dc.subject.keyword | PTV margin | - |
dc.subject.keyword | interfractional setup margin | - |
dc.subject.keyword | interobserver variability | - |
dc.subject.keyword | intrafractional motion | - |
dc.subject.keyword | prostate cancer | - |
dc.contributor.alternativeName | Kim, Jun Won | - |
dc.contributor.affiliatedAuthor | 김준원 | - |
dc.contributor.affiliatedAuthor | 김지훈 | - |
dc.contributor.affiliatedAuthor | 정병하 | - |
dc.contributor.affiliatedAuthor | 조강수 | - |
dc.citation.volume | 13 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN ONCOLOGY, Vol.13, 2023-12 | - |
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