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Large Institutional Experience of Early Outcomes and Dosimetric Findings with Postoperative Stereotactic Partial Breast Irradiation in Breast Cancer
DC Field | Value | Language |
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dc.contributor.author | 김용배 | - |
dc.contributor.author | 김지훈 | - |
dc.contributor.author | 김진성 | - |
dc.contributor.author | 이익재 | - |
dc.contributor.author | 이정심 | - |
dc.contributor.author | 장지석 | - |
dc.contributor.author | 최서희 | - |
dc.date.accessioned | 2024-01-16T01:58:57Z | - |
dc.date.available | 2024-01-16T01:58:57Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 0167-8140 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197813 | - |
dc.description.abstract | Purpose: To analyze the dosimetric and toxicity outcomes of patients treated with postoperative stereotactic partial breast irradiation (S-PBI). Methods: We identified 799 women who underwent S-PBI at our institution between January 2016 and December 2022. The most commonly used dose-fraction and technique were 30 Gy in 5 fractions (91.7%) and a robotic stereotactic radiation system with real-time tracking (83.7%). The primary endpoints were dosimetric parameters and radiation-related toxicities. For comparison, a control group undergoing ultra-hypofractionated whole breast irradiation (UF-WBI, n=468) at the same institution was selected. Results: A total of 815 breasts from 799 patients, with a median planning target volume (PTV) volume of 89.6 cm3, were treated with S-PBI. Treatment plans showed that the mean and maximum doses received by the PTV were 96.2% and 104.8% of the prescription dose, respectively. The volume of the ipsilateral breast that received 50% of the prescription dose was 32.3±8.9%. The mean doses for the ipsilateral lung and heart were 2.5±0.9 Gy and 0.65±0.39 Gy, respectively. Acute toxicity occurred in 175 patients (21.5%), predominantly of grade 1. Overall rate of late toxicity was 4% with a median follow-up of 31.6 months. Compared to the UF-WBI group, the S-PBI group had comparably low acute toxicity (21.5% vs. 25.2%, p=.12) but significantly lower dosimetric parameters for all organs-at-risks (all p<.05). Conclusion: In this large cohort, S-PBI demonstrated favorable dosimetric and toxicity profiles. Considering the reduced radiation exposure to surrounding tissues, external beam PBI with advanced techniques should at least be considered over traditional WBI-based approaches for PBI candidates. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers | - |
dc.relation.isPartOf | RADIOTHERAPY AND ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Large Institutional Experience of Early Outcomes and Dosimetric Findings with Postoperative Stereotactic Partial Breast Irradiation in Breast Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Jeongshim Lee | - |
dc.contributor.googleauthor | Frank A Vicini | - |
dc.contributor.googleauthor | Jin Sung Kim | - |
dc.contributor.googleauthor | Jihun Kim | - |
dc.contributor.googleauthor | Seo Hee Choi | - |
dc.contributor.googleauthor | Ik Jae Lee | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.identifier.doi | 10.1016/j.radonc.2023.110066 | - |
dc.contributor.localId | A00744 | - |
dc.contributor.localId | A05823 | - |
dc.contributor.localId | A04548 | - |
dc.contributor.localId | A03055 | - |
dc.contributor.localId | A03112 | - |
dc.contributor.localId | A04658 | - |
dc.contributor.localId | A04867 | - |
dc.relation.journalcode | J02597 | - |
dc.identifier.eissn | 1879-0887 | - |
dc.identifier.pmid | 38142936 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0167814023093738 | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | 김용배 | - |
dc.contributor.affiliatedAuthor | 김지훈 | - |
dc.contributor.affiliatedAuthor | 김진성 | - |
dc.contributor.affiliatedAuthor | 이익재 | - |
dc.contributor.affiliatedAuthor | 이정심 | - |
dc.contributor.affiliatedAuthor | 장지석 | - |
dc.contributor.affiliatedAuthor | 최서희 | - |
dc.citation.volume | 191 | - |
dc.citation.startPage | 110066 | - |
dc.identifier.bibliographicCitation | RADIOTHERAPY AND ONCOLOGY, Vol.191 : 110066, 2024-02 | - |
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