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Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice

DC Field Value Language
dc.contributor.author이용호-
dc.contributor.author한대훈-
dc.date.accessioned2024-01-16T01:46:58Z-
dc.date.available2024-01-16T01:46:58Z-
dc.date.issued2023-05-
dc.identifier.issn0012-186X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/197737-
dc.description.abstractAims/hypothesis: Non-alcoholic fatty liver disease (NAFLD) associated with type 2 diabetes may more easily progress towards severe forms of non-alcoholic steatohepatitis (NASH) and cirrhosis. Although the Wnt effector transcription factor 7-like 2 (TCF7L2) is closely associated with type 2 diabetes risk, the role of TCF7L2 in NAFLD development remains unclear. Here, we investigated how changes in TCF7L2 expression in the liver affects hepatic lipid metabolism based on the major risk factors of NAFLD development. Methods: Tcf7l2 was selectively ablated in the liver of C57BL/6N mice by inducing the albumin (Alb) promoter to recombine Tcf7l2 alleles floxed at exon 5 (liver-specific Tcf7l2-knockout [KO] mice: Alb-Cre;Tcf7l2-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherSpringer Verlag-
dc.relation.isPartOfDIABETOLOGIA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHDiabetes Mellitus, Type 2* / metabolism-
dc.subject.MESHDiet, High-Fat-
dc.subject.MESHGlucose / metabolism-
dc.subject.MESHHepatocytes / metabolism-
dc.subject.MESHLipogenesis / genetics-
dc.subject.MESHLiver / metabolism-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHNon-alcoholic Fatty Liver Disease* / genetics-
dc.subject.MESHNon-alcoholic Fatty Liver Disease* / metabolism-
dc.subject.MESHTranscription Factor 7-Like 2 Protein / genetics-
dc.subject.MESHTranscription Factor 7-Like 2 Protein / metabolism-
dc.subject.MESHTriglycerides / metabolism-
dc.titleTcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorDa Som Lee-
dc.contributor.googleauthorTae Hyeon An-
dc.contributor.googleauthorHyunmi Kim-
dc.contributor.googleauthorEunsun Jung-
dc.contributor.googleauthorGyeonghun Kim-
dc.contributor.googleauthorSeung Yeon Oh-
dc.contributor.googleauthorJun Seok Kim-
dc.contributor.googleauthorHye Jin Chun-
dc.contributor.googleauthorJaeeun Jung-
dc.contributor.googleauthorEun-Woo Lee-
dc.contributor.googleauthorBaek-Soo Han-
dc.contributor.googleauthorDai Hoon Han-
dc.contributor.googleauthorYong-Ho Lee-
dc.contributor.googleauthorTae-Su Han-
dc.contributor.googleauthorKeun Hur-
dc.contributor.googleauthorChul-Ho Lee-
dc.contributor.googleauthorDae-Soo Kim-
dc.contributor.googleauthorWon Kon Kim-
dc.contributor.googleauthorJun Won Park-
dc.contributor.googleauthorSeung-Hoi Koo-
dc.contributor.googleauthorJe Kyung Seong-
dc.contributor.googleauthorSang Chul Lee-
dc.contributor.googleauthorHail Kim-
dc.contributor.googleauthorKwang-Hee Bae-
dc.contributor.googleauthorKyoung-Jin Oh-
dc.identifier.doi10.1007/s00125-023-05878-8-
dc.contributor.localIdA02989-
dc.contributor.localIdA04273-
dc.relation.journalcodeJ00727-
dc.identifier.eissn1432-0428-
dc.identifier.pmid36759348-
dc.subject.keywordCarbohydrate-
dc.subject.keywordDe novo lipogenesis-
dc.subject.keywordFatty acid-
dc.subject.keywordGlucose-
dc.subject.keywordInsulin-
dc.subject.keywordLipogenesis-
dc.subject.keywordNAFLD-
dc.subject.keywordTCF7L2-
dc.subject.keywordTG accumulation-
dc.subject.keywordType 2 diabetes-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.affiliatedAuthor이용호-
dc.contributor.affiliatedAuthor한대훈-
dc.citation.volume66-
dc.citation.number5-
dc.citation.startPage931-
dc.citation.endPage954-
dc.identifier.bibliographicCitationDIABETOLOGIA, Vol.66(5) : 931-954, 2023-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
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