Cited 1 times in
Diagnosis and Treatment of Monogenic Hypertension in Children
DC Field | Value | Language |
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dc.contributor.author | 신재일 | - |
dc.date.accessioned | 2024-01-03T01:49:21Z | - |
dc.date.available | 2024-01-03T01:49:21Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197669 | - |
dc.description.abstract | Although the majority of individuals with hypertension (HTN) have primary and polygenic HTN, monogenic HTN is a secondary type that is widely thought to play a key role in pediatric HTN, which has the characteristics of early onset, refractory HTN with a positive family history, and electrolyte disorders. Monogenic HTN results from single genetic mutations that contribute to the dysregulation of blood pressure (BP) in the kidneys and adrenal glands. It is pathophysiologically associated with increased sodium reabsorption in the distal tubule, intravascular volume expansion, and HTN, as well as low renin and varying aldosterone levels. Simultaneously increased or decreased potassium levels also provide clues for the diagnosis of monogenic HTN. Discovering the genetic factors that cause an increase in BP has been shown to be related to the choice of and responses to antihypertensive medications. Therefore, early and precise diagnosis with genetic sequencing and effective treatment with accurate antihypertensive agents are critical in the management of monogenic HTN. In addition, understanding the genetic architecture of BP, causative molecular pathways perturbing BP regulation, and pharmacogenomics can help with the selection of precision and personalized medicine, as well as improve morbidity and mortality in adulthood. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antihypertensive Agents / therapeutic use | - |
dc.subject.MESH | Blood Pressure / genetics | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension* / diagnosis | - |
dc.subject.MESH | Hypertension* / drug therapy | - |
dc.subject.MESH | Hypertension* / genetics | - |
dc.subject.MESH | Precision Medicine | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Diagnosis and Treatment of Monogenic Hypertension in Children | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Se Jin Park | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.identifier.doi | 10.3349/ymj.2022.0316 | - |
dc.contributor.localId | A02142 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 36719014 | - |
dc.subject.keyword | Monogenic hypertension | - |
dc.subject.keyword | antihypertensive agent | - |
dc.subject.keyword | genetic mutation | - |
dc.subject.keyword | genetic sequencing | - |
dc.subject.keyword | pediatrics | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.citation.volume | 64 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 77 | - |
dc.citation.endPage | 85 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.64(2) : 77-85, 2023-02 | - |
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