Cited 1 times in
Overgrowth of long bone in rabbits by growth stimulation through metaphyseal hole creation
DC Field | Value | Language |
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dc.contributor.author | 김현우 | - |
dc.contributor.author | 박건보 | - |
dc.contributor.author | 이경미 | - |
dc.contributor.author | 이진우 | - |
dc.date.accessioned | 2024-01-03T01:38:16Z | - |
dc.date.available | 2024-01-03T01:38:16Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197628 | - |
dc.description.abstract | Overgrowth of long bones was noted in pediatric patients who underwent anterior cruciate ligament reconstruction. Hyperaemia during creating a metaphyseal hole and the microinstability made by the drill hole may induce overgrowth. This study aimed to determine whether metaphyseal hole creation accelerates growth and increases bone length and compare the effects of growth stimulation between metaphyseal hole creation and periosteal resection. We selected 7- to 8-week-old male New Zealand white rabbits. Periosteal resection (N = 7) and metaphyseal hole creation (N = 7) were performed on the tibiae of skeletally immature rabbits. Seven additional sham controls were included as age-matched controls. In the metaphyseal hole group, the hole was made using a Steinman pin at the same level of periosteal resection, and the cancellous bone beneath the physis was removed by curettage. The vacant space in the metaphysis below the physis was filled with bone wax. Tibiae were collected 6 weeks after surgery. The operated tibia was longer in the metaphyseal hole group (10.43 ± 0.29 cm vs. 10.65 ± 0.35 cm, P = 0.002). Overgrowth was higher in the metaphyseal hole group (3.17 ± 1.16 mm) than in the sham group (- 0.17 ± 0.39 mm, P < 0.001). The overgrowth in the metaphyseal hole group was comparable to that in the periosteal resection group (2.23 ± 1.52 mm, P = 0.287). In rabbits, metaphyseal hole creation and interposition with bone wax can stimulate long bone overgrowth, and the amount of overgrowth is similar to that seen in periosteal resection. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anterior Cruciate Ligament Reconstruction* | - |
dc.subject.MESH | Cancellous Bone / surgery | - |
dc.subject.MESH | Curettage | - |
dc.subject.MESH | Growth Plate* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Rabbits | - |
dc.subject.MESH | Tibia / diagnostic imaging | - |
dc.subject.MESH | Tibia / surgery | - |
dc.title | Overgrowth of long bone in rabbits by growth stimulation through metaphyseal hole creation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학교실) | - |
dc.contributor.googleauthor | Kyoung-Mi Lee | - |
dc.contributor.googleauthor | Eun Ae Ko | - |
dc.contributor.googleauthor | Mudit Shah | - |
dc.contributor.googleauthor | Seung Eun Oh | - |
dc.contributor.googleauthor | Jin Woo Lee | - |
dc.contributor.googleauthor | Byoung Kyu Park | - |
dc.contributor.googleauthor | Hyun Woo Kim | - |
dc.contributor.googleauthor | Kun-Bo Park\ | - |
dc.identifier.doi | 10.1038/s41598-023-36278-y | - |
dc.contributor.localId | A01124 | - |
dc.contributor.localId | A01418 | - |
dc.contributor.localId | A04619 | - |
dc.contributor.localId | A03230 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 37286806 | - |
dc.contributor.alternativeName | Kim, Hyun Woo | - |
dc.contributor.affiliatedAuthor | 김현우 | - |
dc.contributor.affiliatedAuthor | 박건보 | - |
dc.contributor.affiliatedAuthor | 이경미 | - |
dc.contributor.affiliatedAuthor | 이진우 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 9284 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.13(1) : 9284, 2023-06 | - |
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