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Transcriptomic patterns in early-secretory and mid-secretory endometrium in a natural menstrual cycle immediately before in vitro fertilization and embryo transfer
DC Field | Value | Language |
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dc.contributor.author | 박주현 | - |
dc.contributor.author | 이인하 | - |
dc.contributor.author | 이재훈 | - |
dc.contributor.author | 조시현 | - |
dc.contributor.author | 최영식 | - |
dc.date.accessioned | 2024-01-03T01:29:03Z | - |
dc.date.available | 2024-01-03T01:29:03Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 2287-8572 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197569 | - |
dc.description.abstract | Objective: This study aimed to evaluate the endometrial transcriptomic patterns in the early secretory phase (ESP) and mid-secretory phase (MSP) of the natural menstrual cycle before in vitro fertilization and embryo transfer (IVF-ET). Methods: Thirty patients whose endometrial tissues were obtained from the ESP or MSP of a natural menstrual cycle immediately before IVF-ET were included. Endometrial dating was histologically confirmed as ESP (cycle days 16-18) or MSP (cycle days 19-21), according to the noyes criteria. The patients were divided into two groups depending on the IVF-ET outcome: pregnant (n=14; 7 in ESP and 7 in MSP) or non-pregnant (n=16; 8 in ESP and 8 in MSP). Differentially expressed genes (DEGs) in the MSP, compared to the ESP, were identified using NanoString nCounter (NanoString Technologies, Seattle, WA, USA) data for both the pregnant and non-pregnant groups. Results: Thirteen DEGs in the pregnant group and 11 DEGs in the non-pregnant group were identified in the MSP compared to those in the ESP. In both groups, adrenoceptor alpha 2A, interleukin 1 receptor-associated kinase 2, a disintegrin and metalloproteinase with thrombospondin repeats 15 (ADAMTS15), serpin family E member 1, integrin subunit beta 3, transmembrane protein 252 (TMEM252), huntingtin associated protein 1, C2 calcium-dependent domain containing 4A, and integrin subunit alpha 2 were upregulated in the MSP, compared to the ESP. TMEM37, galactosidase beta 1 like 2, Rho family GTPase 3, and cytochrome P450 family 24 subfamily A member 1 were upregulated in the MSP only in the pregnant group. ADAMTS8 was downregulated and monoamine oxidase A was upregulated in the MSP only in the non-pregnant group. Conclusion: Transcriptomic patterns in the endometrium immediately before IVF-ET appear to differ according to the IVF-ET outcome. These novel DEGs, which have not been previously studied, may have functional significance during the window of implantation and serve as potential biomarkers of endometrial receptivity. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Obstetrics and Gynecology | - |
dc.relation.isPartOf | Obstetrics & Gynecology Science | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Transcriptomic patterns in early-secretory and mid-secretory endometrium in a natural menstrual cycle immediately before in vitro fertilization and embryo transfer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | Sung Pil Choo | - |
dc.contributor.googleauthor | Inha Lee | - |
dc.contributor.googleauthor | Jae-Hoon Lee | - |
dc.contributor.googleauthor | Dowon Lee | - |
dc.contributor.googleauthor | Hyemin Park | - |
dc.contributor.googleauthor | Joo Hyun Park | - |
dc.contributor.googleauthor | SiHyun Cho | - |
dc.contributor.googleauthor | Young Sik Choi | - |
dc.identifier.doi | 10.5468/ogs.22315 | - |
dc.contributor.localId | A01668 | - |
dc.contributor.localId | A05497 | - |
dc.contributor.localId | A04636 | - |
dc.contributor.localId | A03846 | - |
dc.contributor.localId | A04114 | - |
dc.relation.journalcode | J02408 | - |
dc.identifier.eissn | 2287-8580 | - |
dc.identifier.pmid | 37460099 | - |
dc.subject.keyword | Embryo implantation | - |
dc.subject.keyword | Endometrium | - |
dc.subject.keyword | Luteal phase | - |
dc.subject.keyword | Transcriptome | - |
dc.contributor.alternativeName | Park, Joo Hyun | - |
dc.contributor.affiliatedAuthor | 박주현 | - |
dc.contributor.affiliatedAuthor | 이인하 | - |
dc.contributor.affiliatedAuthor | 이재훈 | - |
dc.contributor.affiliatedAuthor | 조시현 | - |
dc.contributor.affiliatedAuthor | 최영식 | - |
dc.citation.volume | 66 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 417 | - |
dc.citation.endPage | 429 | - |
dc.identifier.bibliographicCitation | Obstetrics & Gynecology Science, Vol.66(5) : 417-429, 2023-09 | - |
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