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Effects of Dihydropyridines on the Motor and Cognitive Outcomes of Patients with Parkinson's Disease

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dc.contributor.author손영호-
dc.contributor.author유한수-
dc.contributor.author이양현-
dc.contributor.author이필휴-
dc.contributor.author정석종-
dc.contributor.author나한규-
dc.contributor.author백경원-
dc.date.accessioned2024-01-03T01:24:25Z-
dc.date.available2024-01-03T01:24:25Z-
dc.date.issued2023-05-
dc.identifier.issn0885-3185-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/197547-
dc.description.abstractBackground: Dihydropyridines (DHPs) may have neuroprotective effects against Parkinson's disease (PD). Objective: This study investigated the effects of DHPs on nigrostriatal dopaminergic denervation and longitudinal motor and cognitive outcomes in PD. Methods: We classified 476 patients with drug-naive PD who had undergone dopamine transporter imaging into three groups. They were selected according to a prior diagnosis of hypertension and use of DHPs and were matched using propensity scores: patients without hypertension (HTN-; n = 50) and patients with hypertension treated without DHP (HTN+/DHP-; n = 50) or with DHP (HTN+/DHP+; n = 50). Multiple linear regression and linear mixed model analyses were performed to determine intergroup differences in baseline dopamine transporter availability and longitudinal changes in the levodopa-equivalent dose, respectively. Using Kaplan-Meier analyses, we compared the risks of levodopa-induced dyskinesia, wearing off, and dementia-free survival during the 5.06 years of the mean follow-up period. The Cox regression model determined the independent effects of DHPs on dementia conversion. Results: Dopamine transporter availability in all striatal subregions was comparable between the HTN-, HTN+/DHP-, and HTN+/DHP+ groups. The risks of levodopa-induced dyskinesia and wearing off, as well as longitudinal changes in the levodopa-equivalent dose, did not differ between the groups. The HTN+/DHP+ group had a lower risk of developing dementia than the HTN+/DHP- (Bonferroni-corrected Plog-rank = 0.036) group. The use of DHP was independently associated with a lower risk of dementia conversion after controlling for other antihypertensive drugs and confounding factors (hazard ratio, 0.242; 95% confidence interval, 0.087-0.668; P = 0.006). Conclusions: DHPs may be associated with better long-term cognitive outcomes in hypertensive patients with PD. © 2023 International Parkinson and Movement Disorder Society.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfMOVEMENT DISORDERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAntiparkinson Agents / adverse effects-
dc.subject.MESHCognition-
dc.subject.MESHDihydropyridines* / therapeutic use-
dc.subject.MESHDopamine Plasma Membrane Transport Proteins-
dc.subject.MESHDyskinesias* / drug therapy-
dc.subject.MESHHumans-
dc.subject.MESHHypertension* / drug therapy-
dc.subject.MESHLevodopa / adverse effects-
dc.subject.MESHParkinson Disease* / complications-
dc.subject.MESHParkinson Disease* / drug therapy-
dc.titleEffects of Dihydropyridines on the Motor and Cognitive Outcomes of Patients with Parkinson's Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorJin Ho Jung-
dc.contributor.googleauthorHan Kyu Na-
dc.contributor.googleauthorSeong Ho Jeong-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorHan Soo Yoo-
dc.contributor.googleauthorYang Hyun Lee-
dc.contributor.googleauthorKyoungwon Baik-
dc.contributor.googleauthorSang Jin Kim-
dc.contributor.googleauthorYoung H Sohn-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1002/mds.29367-
dc.contributor.localIdA01982-
dc.contributor.localIdA05367-
dc.contributor.localIdA05714-
dc.contributor.localIdA03270-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ02275-
dc.identifier.eissn1531-8257-
dc.identifier.pmid36825772-
dc.identifier.urlhttps://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.29367-
dc.subject.keywordParkinson's disease-
dc.subject.keywordcalcium channel blocker-
dc.subject.keyworddementia-
dc.subject.keyworddihydropyridine-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume38-
dc.citation.number5-
dc.citation.startPage843-
dc.citation.endPage853-
dc.identifier.bibliographicCitationMOVEMENT DISORDERS, Vol.38(5) : 843-853, 2023-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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