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Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis
DC Field | Value | Language |
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dc.contributor.author | 지종현 | - |
dc.date.accessioned | 2024-01-03T01:17:18Z | - |
dc.date.available | 2024-01-03T01:17:18Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2211-9132 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197516 | - |
dc.description.abstract | Background: Alternative complement pathway dysregulation plays a key role in glomerulonephritis (GN) and is associated with C3 deposition. Herein, we examined pathological and clinical differences between cases of primary GN with C3-dominant (C3D-GN) and nondominant (C3ND-GN) deposition. Methods: We extracted primary GN data from the Korean GlomeruloNEphritis sTudy (KoGNET). C3D-GN was defined as C3 staining two grades greater than C1q, C4, and immunoglobulin via immunofluorescence analysis. To overcome a large difference in the number of patients between the C3D-GN and C3ND-GN groups (31 vs. 9,689), permutation testing was used for analysis. Results: The C3D-GN group exhibited higher serum creatinine (p ≤ 0.001), a greater prevalence of estimated glomerular filtration rate of <60 mL/min/1.72 m2 (p ≤ 0.001), higher (but not significantly so) C-reactive protein level, and lower serum C3 level (p ≤ 0.001). Serum albumin, urine protein/creatinine ratio, number of patients who progressed to end-stage renal disease, and all-cause mortality were comparable between groups. Interstitial fibrosis and mesangial cellularity were greater in the C3D-GN group (p = 0.04 and p = 0.01, respectively) than in the C3ND-GN group. C3 deposition was dominant in the former group (p < 0.001), in parallel with increased subendothelial deposition (p ≤ 0.001). Conclusion: Greater progression of renal injury and higher mortality occurred in patients with C3D-GN than with C3ND-GN, along with pathologic differences in interstitial and mesangial changes. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier Korea | - |
dc.relation.isPartOf | KIDNEY RESEARCH AND CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Comparison of dominant and nondominant C3 deposition in primary glomerulonephritis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jiwon Ryu | - |
dc.contributor.googleauthor | Eunji Baek | - |
dc.contributor.googleauthor | Hyung-Eun Son | - |
dc.contributor.googleauthor | Ji-Young Ryu | - |
dc.contributor.googleauthor | Jong Cheol Jeong | - |
dc.contributor.googleauthor | Sejoong Kim | - |
dc.contributor.googleauthor | Ki Young Na | - |
dc.contributor.googleauthor | Dong-Wan Chae | - |
dc.contributor.googleauthor | Seong Pyo Kim | - |
dc.contributor.googleauthor | Su Hwan Kim | - |
dc.contributor.googleauthor | Jong Hyun Jhee | - |
dc.contributor.googleauthor | Tae Ik Chang | - |
dc.contributor.googleauthor | Bum Soon Choi | - |
dc.contributor.googleauthor | Ho Jun Chin | - |
dc.identifier.doi | 10.23876/j.krcp.22.042 | - |
dc.contributor.localId | A03970 | - |
dc.relation.journalcode | J01942 | - |
dc.identifier.eissn | 2211-9140 | - |
dc.identifier.pmid | 36747358 | - |
dc.subject.keyword | Alternative pathway | - |
dc.subject.keyword | Complement system C3 convertase | - |
dc.subject.keyword | Glomerulonephritis | - |
dc.contributor.alternativeName | Jhee, Jong Hyun | - |
dc.contributor.affiliatedAuthor | 지종현 | - |
dc.citation.volume | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 98 | - |
dc.citation.endPage | 108 | - |
dc.identifier.bibliographicCitation | KIDNEY RESEARCH AND CLINICAL PRACTICE, Vol.42(1) : 98-108, 2023-01 | - |
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