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Impact of guideline-directed medical therapy on 5-year mortality in patients with newly diagnosed peripheral artery disease
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 안철민 | - |
dc.date.accessioned | 2024-01-03T01:16:55Z | - |
dc.date.available | 2024-01-03T01:16:55Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 0741-5214 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197511 | - |
dc.description.abstract | Objective: Current guidelines recommend that patients with peripheral artery disease (PAD) should be treated with antithrombotic agents, renin-angiotensin-system blockers, and statins. However, the clinical impact of guideline-directed medical therapy (GDMT) on long-term mortality in patients with newly diagnosed PAD remains unclear. We aimed to investigate the prevalence of GDMT and evaluate 5-year mortality according to GDMT after PAD diagnosis. Methods: This retrospective cohort study, using nationwide health insurance claims data in Korea, included patients newly diagnosed with PAD between 2006 and 2015. GDMT was defined as the use of all drugs, including antithrombotic agents, renin-angiotensin-system blockers, and statins, within 3 months of PAD diagnosis. The primary endpoint was all-cause mortality. Results: We investigated 19,561 newly diagnosed patients with PAD without proven cardiovascular disease. Among the study population, 4378 patients (22.4%) were categorized in the GDMT and 15,183 (77.6%) in the non-GDMT groups. During the 5-year follow-up, GDMT showed a lower incidence of all-cause mortality than that of non-GDMT (2.8% vs 4.8%; adjusted hazard ratio, 0.329; 95% confidence interval, 0.257-0.421; P < .001). Even in the propensity-matched population, GDMT showed a lower mortality rate than non-GDMT (hazard ratio, 0.283; 95% confidence interval, 0.217-0.370; P < .001). As the number of guideline-recommended drugs increased, the mortality rate decreased proportionately. Conclusions: After PAD diagnosis, GDMT was associated with a lower incidence of mortality regardless of proven cardiovascular disease. This retrospective analysis showed an insufficient prevalence of GDMT among patients with PAD in real-world practice. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF VASCULAR SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Angiotensins | - |
dc.subject.MESH | Fibrinolytic Agents | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydroxymethylglutaryl-CoA Reductase Inhibitors* / therapeutic use | - |
dc.subject.MESH | Peripheral Arterial Disease* / diagnosis | - |
dc.subject.MESH | Peripheral Arterial Disease* / drug therapy | - |
dc.subject.MESH | Renin | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Impact of guideline-directed medical therapy on 5-year mortality in patients with newly diagnosed peripheral artery disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jung-Hee Lee | - |
dc.contributor.googleauthor | Ho Sung Jeon | - |
dc.contributor.googleauthor | Jun-Won Lee | - |
dc.contributor.googleauthor | Young Jin Youn | - |
dc.contributor.googleauthor | Sung Gyun Ahn | - |
dc.contributor.googleauthor | Hoseob Kim | - |
dc.contributor.googleauthor | Yoonjong Bae | - |
dc.contributor.googleauthor | Ung Kim | - |
dc.contributor.googleauthor | Chul-Min Ahn | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.identifier.doi | 10.1016/j.jvs.2023.08.103 | - |
dc.contributor.localId | A00127 | - |
dc.contributor.localId | A02269 | - |
dc.relation.journalcode | J01924 | - |
dc.identifier.eissn | 1097-6809 | - |
dc.identifier.pmid | 37597591 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0741521423018669 | - |
dc.subject.keyword | Guideline | - |
dc.subject.keyword | Medication therapy management | - |
dc.subject.keyword | Mortality | - |
dc.subject.keyword | Peripheral arterial disease | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.affiliatedAuthor | 고영국 | - |
dc.contributor.affiliatedAuthor | 안철민 | - |
dc.citation.volume | 78 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1471 | - |
dc.citation.endPage | 1478.e3 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VASCULAR SURGERY, Vol.78(6) : 1471-1478.e3, 2023-12 | - |
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