Cited 1 times in
CD4/CD8 Ratio Recovery Among People Living With HIV Starting With First-Line Integrase Strand Transfer Inhibitors: A Prospective Regional Cohort Analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최준용 | - |
dc.date.accessioned | 2024-01-03T00:59:00Z | - |
dc.date.available | 2024-01-03T00:59:00Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 1525-4135 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197420 | - |
dc.description.abstract | Background: We evaluated trends in CD4/CD8 ratio among people living with HIV (PLWH) starting antiretroviral therapy (ART) with first-line integrase strand transfer inhibitors (INSTI) compared with non-INSTI-based ART, and the incidence of CD4/CD8 ratio normalization. Methods: All PLWH enrolled in adult HIV cohorts of IeDEA Asia-Pacific who started with triple-ART with at least 1 CD4, CD8 (3-month window), and HIV-1 RNA measurement post-ART were included. CD4/CD8 ratio normalization was defined as a ratio ≥1. Longitudinal changes in CD4/CD8 ratio were analyzed by linear mixed model, the incidence of the normalization by Cox regression, and the differences in ratio recovery by group-based trajectory modeling. Results: A total of 5529 PLWH were included; 80% male, median age 35 years (interquartile range [IQR], 29-43). First-line regimens were comprised of 65% NNRTI, 19% PI, and 16% INSTI. The baseline CD4/CD8 ratio was 0.19 (IQR, 0.09-0.33). PLWH starting with NNRTI- (P = 0.005) or PI-based ART (P = 0.030) had lower CD4/CD8 recovery over 5 years compared with INSTI. During 24,304 person-years of follow-up, 32% had CD4/CD8 ratio normalization. After adjusting for age, sex, baseline CD4, HIV-1 RNA, HCV, and year of ART initiation, PLWH started with INSTI had higher odds of achieving CD4/CD8 ratio normalization than NNRTI- (P < 0.001) or PI-based ART (P = 0.015). In group-based trajectory modeling analysis, INSTI was associated with greater odds of being in the higher ratio trajectory. Conclusions: INSTI use was associated with higher rates of CD4/CD8 ratio recovery and normalization in our cohort. These results emphasize the relative benefits of INSTI-based ART for immune restoration. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins, Inc. | - |
dc.relation.isPartOf | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | CD4-CD8 Ratio | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | HIV Infections* / drug therapy | - |
dc.subject.MESH | HIV Integrase Inhibitors* / therapeutic use | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Integrases | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | RNA / therapeutic use | - |
dc.title | CD4/CD8 Ratio Recovery Among People Living With HIV Starting With First-Line Integrase Strand Transfer Inhibitors: A Prospective Regional Cohort Analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Win Min Han | - |
dc.contributor.googleauthor | Anchalee Avihingsanon | - |
dc.contributor.googleauthor | Reena Rajasuriar | - |
dc.contributor.googleauthor | Junko Tanuma | - |
dc.contributor.googleauthor | Sanjay Mundhe | - |
dc.contributor.googleauthor | Man-Po Lee | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Sanjay Pujari | - |
dc.contributor.googleauthor | Yu-Jiun Chan | - |
dc.contributor.googleauthor | Agus Somia | - |
dc.contributor.googleauthor | Fujie Zhang | - |
dc.contributor.googleauthor | Nagalingeswaran Kumarasamy | - |
dc.contributor.googleauthor | Oon Tek Ng | - |
dc.contributor.googleauthor | Yasmin Gani | - |
dc.contributor.googleauthor | Romanee Chaiwarith | - |
dc.contributor.googleauthor | Thach Ngoc Pham | - |
dc.contributor.googleauthor | Cuong Duy Do | - |
dc.contributor.googleauthor | Rossana Ditangco | - |
dc.contributor.googleauthor | Sasisopin Kiertiburanakul | - |
dc.contributor.googleauthor | Vohith Khol | - |
dc.contributor.googleauthor | Jeremy Ross | - |
dc.contributor.googleauthor | Awachana Jiamsakul | - |
dc.contributor.googleauthor | IeDEA Asia‐Pacific | - |
dc.identifier.doi | 10.1097/QAI.0000000000003121 | - |
dc.contributor.localId | A04191 | - |
dc.relation.journalcode | J01195 | - |
dc.identifier.eissn | 1944-7884 | - |
dc.identifier.pmid | 36625858 | - |
dc.identifier.url | https://journals.lww.com/jaids/fulltext/2023/02010/cd4_cd8_ratio_recovery_among_people_living_with.11 | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | 최준용 | - |
dc.citation.volume | 92 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 180 | - |
dc.citation.endPage | 188 | - |
dc.identifier.bibliographicCitation | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol.92(2) : 180-188, 2023-02 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.