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Changes in Autonomic Nervous System Activity in Children With Spina Bifida: A Case-Control Study
DC Field | Value | Language |
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dc.contributor.author | 김상운 | - |
dc.contributor.author | 이용승 | - |
dc.contributor.author | 한상원 | - |
dc.date.accessioned | 2024-01-03T00:55:04Z | - |
dc.date.available | 2024-01-03T00:55:04Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 2093-4777 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197407 | - |
dc.description.abstract | Purpose: We compared heart rate variability parameters between patients with spina bifida and a control group during urodynamic studies, with the goal of evaluating the autonomic nervous system dysfunction present in spina bifida. Methods: Continuous heart rate variability parameters were recorded during 3 successive periods (P0, the 2 minutes prior to the start of filling; P1, from the start of filling to the first desire to void; and P2, from P1 to the end of filling or the start of voiding). The control group consisted of children with vesicoureteral reflux who had undergone video-urodynamic studies. Our study included 11 patients with spina bifida and 9 control participants. Results: At baseline, patients with spina bifida exhibited lower values for the root mean square of successive differences in NN intervals, the percentage of successive R-R interval differences exceeding 50 msec relative to the total number of intervals, and high frequency (HF). In contrast, the low frequency (LF)/HF ratio was elevated in these patients (5.04 ± 4.75 vs. 0.67 ± 0.42, P = 0.014). During bladder filling, LF/HF values increased in the control group (P0, 0.67 ± 0.42; P1, 0.89 ± 0.34; P2, 1.21 ± 0.64; P = 0.018), while they declined in patients with spina bifida (P0, 5.04 ± 4.75; P1, 3.96 ± 4.35; P2, 3.26 ± 4.03; P < 0.001). The HF values were significantly elevated in children with spina bifida during bladder filling (P = 0.002). In the time domain, the standard deviations of all NN intervals were elevated only in the control group during bladder filling. Parasympathetic activity domains were reduced in the children with spina bifida at the initial assessment. Conclusion: During the bladder filling phase, parasympathetic activity increased along with fixed sympathetic activity in the spina bifida group. In contrast, the control group exhibited a shift towards a sympathetic preponderance at the conclusion of bladder filling. These observations may be associated with the pathophysiology of neurogenic bladder in spina bifida. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한배뇨장애 및 요실금학회 | - |
dc.relation.isPartOf | INTERNATIONAL NEUROUROLOGY JOURNAL(대한배뇨장애요실금학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Changes in Autonomic Nervous System Activity in Children With Spina Bifida: A Case-Control Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Byeong Seon Kim | - |
dc.contributor.googleauthor | Israel Franco | - |
dc.contributor.googleauthor | Yong Seung Lee | - |
dc.contributor.googleauthor | Sang Won Han | - |
dc.contributor.googleauthor | Sang Woon Kim | - |
dc.identifier.doi | 10.5213/inj.2346080.040 | - |
dc.contributor.localId | A00527 | - |
dc.contributor.localId | A02980 | - |
dc.contributor.localId | A04285 | - |
dc.relation.journalcode | J01817 | - |
dc.identifier.pmid | 37798886 | - |
dc.subject.keyword | Autonomic nervous system | - |
dc.subject.keyword | Spinal dysraphism | - |
dc.subject.keyword | Urinary bladder, Neurogenic | - |
dc.subject.keyword | Urodynamics | - |
dc.contributor.alternativeName | Kim, Sang Woon | - |
dc.contributor.affiliatedAuthor | 김상운 | - |
dc.contributor.affiliatedAuthor | 이용승 | - |
dc.contributor.affiliatedAuthor | 한상원 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 192 | - |
dc.citation.endPage | 199 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL NEUROUROLOGY JOURNAL, Vol.27(3) : 192-199, 2023-09 | - |
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