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Hepatic Steatosis but Not Fibrosis Is Independently Associated with Poor Outcomes in Patients with Inflammatory Bowel Dise

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dc.contributor.author김도영-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author김태일-
dc.contributor.author박수정-
dc.contributor.author박재준-
dc.contributor.author박준용-
dc.contributor.author박지혜-
dc.contributor.author안상훈-
dc.contributor.author이재승-
dc.contributor.author이혜원-
dc.contributor.author천재희-
dc.contributor.author현혜경-
dc.date.accessioned2024-01-03T00:44:49Z-
dc.date.available2024-01-03T00:44:49Z-
dc.date.issued2023-
dc.identifier.issn1976-2283-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/197359-
dc.description.abstractBackground/aims: Increased prevalence of nonalcoholic fatty liver disease (NAFLD) and inflammatory bowel disease (IBD) has been reported. However, the effects of NAFLD on the outcome of IBD remains unclear. We investigated whether the presence of NAFLD could influence the outcomes of patients with IBD. Methods: We recruited 3,356 eligible patients with IBD into our study between November 2005 and November 2020. Hepatic steatosis and fibrosis were diagnosed using hepatic steatosis index of ≥30 and fibrosis-4 of ≥1.45, respectively. The primary outcome was clinical relapse, defined based on the following: IBD-related admission, surgery, or first use of corticosteroids, immunomodulators, or biologic agents for IBD. Results: The prevalence of NAFLD in patients with IBD was 16.7%. Patients with hepatic steatosis and advanced fibrosis were older, had a higher body mass index, and were more likely to have diabetes (all p<0.05). Conclusions: Hepatic steatosis was independently associated with increased risks of clinical relapse in patients with ulcerative colitis and Crohn's disease, whereas fibrotic burden in the liver was not. Future studies should investigate whether assessment and therapeutic intervention for NAFLD will improve the clinical outcomes of patients with IBD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherEditorial Office of Gut and Liver-
dc.relation.isPartOfGUT AND LIVER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHepatic Steatosis but Not Fibrosis Is Independently Associated with Poor Outcomes in Patients with Inflammatory Bowel Dise-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHye Kyung Hyun-
dc.contributor.googleauthorHye Won Lee-
dc.contributor.googleauthorJihye Park-
dc.contributor.googleauthorSoo Jung Park-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorJae Seung Lee-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorJae Hee Cheon-
dc.identifier.doi10.5009/gnl220409-
dc.contributor.localIdA00385-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA01079-
dc.contributor.localIdA01539-
dc.contributor.localIdA01636-
dc.contributor.localIdA01675-
dc.contributor.localIdA04575-
dc.contributor.localIdA02226-
dc.contributor.localIdA05963-
dc.contributor.localIdA03318-
dc.contributor.localIdA04030-
dc.contributor.localIdA06135-
dc.relation.journalcodeJ00954-
dc.identifier.eissn2005-1212-
dc.identifier.pmid37203442-
dc.identifier.urlhttps://www.gutnliver.org/journal/view.html?doi=10.5009/gnl220409-
dc.subject.keywordHepatic steatosis-
dc.subject.keywordInflammatory bowel diseases-
dc.subject.keywordLiver fibrosis-
dc.subject.keywordNon-alcoholic fatty liver disease-
dc.subject.keywordOutcome-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.affiliatedAuthor김도영-
dc.contributor.affiliatedAuthor김범경-
dc.contributor.affiliatedAuthor김승업-
dc.contributor.affiliatedAuthor김태일-
dc.contributor.affiliatedAuthor박수정-
dc.contributor.affiliatedAuthor박재준-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor박지혜-
dc.contributor.affiliatedAuthor안상훈-
dc.contributor.affiliatedAuthor이재승-
dc.contributor.affiliatedAuthor이혜원-
dc.contributor.affiliatedAuthor천재희-
dc.contributor.affiliatedAuthor현혜경-
dc.citation.startPageepub-
dc.identifier.bibliographicCitationGUT AND LIVER, : epub, 2023-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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