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Lymphovascular invasion is an independent prognostic factor in breast cancer irrespective of axillary node metastasis and molecular subtypes

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dc.contributor.author김승일-
dc.contributor.author김지예-
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.contributor.author박형석-
dc.contributor.author안지현-
dc.contributor.author이석준-
dc.date.accessioned2024-01-03T00:43:18Z-
dc.date.available2024-01-03T00:43:18Z-
dc.date.issued2023-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/197351-
dc.description.abstractPurpose: Lymphovascular invasion (LVI) is a well-known poor prognostic factor for early breast cancer. However, the effect of LVI on breast cancer subtype and node status remains unknown. In this study, we aimed to evaluate the clinical significance of LVI on the recurrence and long-term survival of patients with early breast cancer by comparing groups according to the subtype and node status. Methods: We retrospectively reviewed the medical records of 4554 patients with breast cancer who underwent breast cancer surgery between January 2010 and December 2017. The primary endpoints were disease-free survival (DFS) and overall survival (OS). Univariate and multivariate analyses were performed to identify prognostic factors related to the DFS and OS according to the nodal status and breast cancer subtype. Results: During a follow-up period of 94 months, the median OS and DFS were 92 and 90 months, respectively. The LVI expression rate was 8.4%. LVI had a negative impact on the DFS and OS, regardless of the lymph node status. LVI was associated with higher recurrence and lower survival in the luminal A, human epidermal growth factor receptor 2-positive, and triple-negative breast cancer subtypes. The Cox proportional hazards model showed that LVI was a significant prognostic factor for both DFS and OS. No correlation has been observed between LVI and the Oncotype Dx results in terms of prognostic value in early breast cancer. Conclusion: LVI is an independent poor prognostic factor in patients with early breast cancer, regardless of the node status and molecular subtype. Therefore, the LVI status should be considered when making treatment decisions for patients with early stage breast cancer; however, further prospective studies are warranted.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleLymphovascular invasion is an independent prognostic factor in breast cancer irrespective of axillary node metastasis and molecular subtypes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorSuk Jun Lee-
dc.contributor.googleauthorJieon Go-
dc.contributor.googleauthorByung Soo Ahn-
dc.contributor.googleauthorJee Hyun Ahn-
dc.contributor.googleauthorJee Ye Kim-
dc.contributor.googleauthorHyung Seok Park-
dc.contributor.googleauthorSeung Il Kim-
dc.contributor.googleauthorByeong-Woo Park-
dc.contributor.googleauthorSeho Park-
dc.identifier.doi10.3389/fonc.2023.1269971-
dc.contributor.localIdA00658-
dc.contributor.localIdA00984-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.contributor.localIdA01753-
dc.contributor.localIdA06150-
dc.relation.journalcodeJ03512-
dc.identifier.eissn2234-943X-
dc.identifier.pmid38053656-
dc.subject.keywordbreast cancer-
dc.subject.keywordbreast cancer subtypes-
dc.subject.keywordlymphovascular invasion-
dc.subject.keywordnode metastasis-
dc.subject.keywordoncotype Dx-
dc.contributor.alternativeNameKim, Seung Il-
dc.contributor.affiliatedAuthor김승일-
dc.contributor.affiliatedAuthor김지예-
dc.contributor.affiliatedAuthor박병우-
dc.contributor.affiliatedAuthor박세호-
dc.contributor.affiliatedAuthor박형석-
dc.contributor.affiliatedAuthor안지현-
dc.citation.volume13-
dc.citation.startPage1269971-
dc.identifier.bibliographicCitationFRONTIERS IN ONCOLOGY, Vol.13 : 1269971, 2023-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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