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Role of histamine-mediated macrophage differentiation in clearance of metastatic bacterial infection
DC Field | Value | Language |
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dc.contributor.author | 남기택 | - |
dc.contributor.author | 김광휘 | - |
dc.date.accessioned | 2024-01-03T00:41:58Z | - |
dc.date.available | 2024-01-03T00:41:58Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197340 | - |
dc.description.abstract | Macrophages are highly heterogeneous immune cells with a role in maintaining tissue homeostasis, especially in activating the defense response to bacterial infection. Using flow cytometric and single-cell RNA-sequencing analyses of peritoneal cells, we here show that small peritoneal macrophage and immature macrophage populations are enriched in histamine-deficient (Hdc -/-) mice, characterized by a CD11bmiF4/80loCCR2+MHCIIhi and CD11bloF4/80miTHBS1+IL-1α+ phenotype, respectively. Molecular characterization revealed that immature macrophages represent an abnormally differentiated form of large peritoneal macrophages with strong inflammatory properties. Furthermore, deficiency in histamine signaling resulted in significant impairment of the phagocytic activity of peritoneal macrophage populations, conferring high susceptibility to bacterial infection. Collectively, this study reveals the importance of histamine signaling in macrophage differentiation at the molecular level to maintain tissue homeostasis, offering a potential therapeutic target for bacterial infection-mediated diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Histamine* | - |
dc.subject.MESH | Macrophages* | - |
dc.subject.MESH | Macrophages, Peritoneal | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Phagocytes | - |
dc.title | Role of histamine-mediated macrophage differentiation in clearance of metastatic bacterial infection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Kwang H Kim | - |
dc.contributor.googleauthor | Donghwan Park | - |
dc.contributor.googleauthor | Soo Young Cho | - |
dc.contributor.googleauthor | Yejin Cho | - |
dc.contributor.googleauthor | Buhyun Lee | - |
dc.contributor.googleauthor | Haengdueng Jeong | - |
dc.contributor.googleauthor | Yura Lee | - |
dc.contributor.googleauthor | Yourim Lee | - |
dc.contributor.googleauthor | Ki Taek Nam | - |
dc.identifier.doi | 10.3389/fimmu.2023.1290191 | - |
dc.contributor.localId | A01243 | - |
dc.relation.journalcode | J03075 | - |
dc.identifier.eissn | 1664-3224 | - |
dc.identifier.pmid | 38035074 | - |
dc.subject.keyword | bacterial infection | - |
dc.subject.keyword | histamine | - |
dc.subject.keyword | macrophage differentiation | - |
dc.subject.keyword | peritoneal cells | - |
dc.subject.keyword | single-cell RNA sequencing | - |
dc.contributor.alternativeName | Nam, Ki Taek | - |
dc.contributor.affiliatedAuthor | 남기택 | - |
dc.citation.volume | 14 | - |
dc.citation.startPage | 1290191 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN IMMUNOLOGY, Vol.14 : 1290191, 2023-11 | - |
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