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Retreatment after loss to follow-up reduces mortality in patients with multidrug/rifampicin-resistant tuberculosis
DC Field | Value | Language |
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dc.contributor.author | 강영애 | - |
dc.date.accessioned | 2024-01-03T00:35:28Z | - |
dc.date.available | 2024-01-03T00:35:28Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197310 | - |
dc.description.abstract | Background: This study evaluated the risk factors of long-term mortality in patients with multidrug/rifampicin-resistant tuberculosis (MDR/RR-TB) in South Korea who were lost to follow-up (LTFU). Methods: This was a retrospective longitudinal follow-up study using an integrated database constructed by data linkage of the three national databases, which included 7226 cases of MDR/RR-TB notified between 2011 and 2017 in South Korea. Post-treatment outcomes of patients who were LTFU were compared with those of patients who achieved treatment success. Results: Of the 7226 MDR/RR-TB cases, 730 (10.1%) were LTFU. During a median follow-up period of 4.2 years, 101 (13.8%) of the LTFU patients died: 25 deaths (3.4%) were TB related and 76 (10.4%) were non-TB related. In the LTFU group, the adjusted hazard ratio (aHR) of all-cause mortality (aHR 2.50, 95% CI 1.99-3.15, p<0.001), TB-related mortality (aHR 5.38, 95% CI 3.19-9.09, p<0.001) and non-TB-related mortality (HR 2.21, 95% CI 1.70-2.87, p<0.001) was significantly higher than that in the treatment success group. Independent risk factors for all-cause mortality in the LTFU group were age >55 years, fluoroquinolone resistance, cancer and no retreatment. In the LTFU patients who did not receive retreatment, the risk of non-TB-related mortality (aHR 5.00, 95% CI 1.53-16.37, p=0.008) and consequent all-cause mortality (aHR 2.18, 95% CI 1.08-4.40, p=0.030) was significantly higher than that of patients who received retreatment. Conclusion: Non-TB-related mortality was the main cause of death and might be reduced by retreatment in LTFU patients with MDR/RR-TB. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | European Respiratory Society | - |
dc.relation.isPartOf | ERJ OPEN RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Retreatment after loss to follow-up reduces mortality in patients with multidrug/rifampicin-resistant tuberculosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hongjo Choi | - |
dc.contributor.googleauthor | Jeongha Mok | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.contributor.googleauthor | Dawoon Jeong | - |
dc.contributor.googleauthor | Hee-Yeon Kang | - |
dc.contributor.googleauthor | Hee Jin Kim | - |
dc.contributor.googleauthor | Hee-Sun Kim | - |
dc.contributor.googleauthor | Doosoo Jeon | - |
dc.identifier.doi | 10.1183/23120541.00135-2023 | - |
dc.contributor.localId | A00057 | - |
dc.relation.journalcode | J04513 | - |
dc.identifier.eissn | 2312-0541 | - |
dc.identifier.pmid | 37583964 | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | 강영애 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 00135-2023 | - |
dc.identifier.bibliographicCitation | ERJ OPEN RESEARCH, Vol.9(4) : 00135-2023, 2023-08 | - |
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