34 78

Cited 0 times in

Retreatment after loss to follow-up reduces mortality in patients with multidrug/rifampicin-resistant tuberculosis

DC Field Value Language
dc.contributor.author강영애-
dc.date.accessioned2024-01-03T00:35:28Z-
dc.date.available2024-01-03T00:35:28Z-
dc.date.issued2023-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/197310-
dc.description.abstractBackground: This study evaluated the risk factors of long-term mortality in patients with multidrug/rifampicin-resistant tuberculosis (MDR/RR-TB) in South Korea who were lost to follow-up (LTFU). Methods: This was a retrospective longitudinal follow-up study using an integrated database constructed by data linkage of the three national databases, which included 7226 cases of MDR/RR-TB notified between 2011 and 2017 in South Korea. Post-treatment outcomes of patients who were LTFU were compared with those of patients who achieved treatment success. Results: Of the 7226 MDR/RR-TB cases, 730 (10.1%) were LTFU. During a median follow-up period of 4.2 years, 101 (13.8%) of the LTFU patients died: 25 deaths (3.4%) were TB related and 76 (10.4%) were non-TB related. In the LTFU group, the adjusted hazard ratio (aHR) of all-cause mortality (aHR 2.50, 95% CI 1.99-3.15, p<0.001), TB-related mortality (aHR 5.38, 95% CI 3.19-9.09, p<0.001) and non-TB-related mortality (HR 2.21, 95% CI 1.70-2.87, p<0.001) was significantly higher than that in the treatment success group. Independent risk factors for all-cause mortality in the LTFU group were age >55 years, fluoroquinolone resistance, cancer and no retreatment. In the LTFU patients who did not receive retreatment, the risk of non-TB-related mortality (aHR 5.00, 95% CI 1.53-16.37, p=0.008) and consequent all-cause mortality (aHR 2.18, 95% CI 1.08-4.40, p=0.030) was significantly higher than that of patients who received retreatment. Conclusion: Non-TB-related mortality was the main cause of death and might be reduced by retreatment in LTFU patients with MDR/RR-TB.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherEuropean Respiratory Society-
dc.relation.isPartOfERJ OPEN RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleRetreatment after loss to follow-up reduces mortality in patients with multidrug/rifampicin-resistant tuberculosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHongjo Choi-
dc.contributor.googleauthorJeongha Mok-
dc.contributor.googleauthorYoung Ae Kang-
dc.contributor.googleauthorDawoon Jeong-
dc.contributor.googleauthorHee-Yeon Kang-
dc.contributor.googleauthorHee Jin Kim-
dc.contributor.googleauthorHee-Sun Kim-
dc.contributor.googleauthorDoosoo Jeon-
dc.identifier.doi10.1183/23120541.00135-2023-
dc.contributor.localIdA00057-
dc.relation.journalcodeJ04513-
dc.identifier.eissn2312-0541-
dc.identifier.pmid37583964-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.affiliatedAuthor강영애-
dc.citation.volume9-
dc.citation.number4-
dc.citation.startPage00135-2023-
dc.identifier.bibliographicCitationERJ OPEN RESEARCH, Vol.9(4) : 00135-2023, 2023-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.