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Association Between Lipid Profile and Risk of Incident Systemic Sclerosis: A Nationwide Population-Based Study
DC Field | Value | Language |
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dc.contributor.author | 권오찬 | - |
dc.contributor.author | 박민찬 | - |
dc.date.accessioned | 2024-01-03T00:31:46Z | - |
dc.date.available | 2024-01-03T00:31:46Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197282 | - |
dc.description.abstract | Background and aims: Lipid metabolism is altered in systemic sclerosis (SSc), mediating activation of immune cells and fibroblasts. However, it is unclear whether altered lipid profile is associated with a risk of developing SSc. We aimed to assess the association between lipid profile and risk of incident SSc. Methods: From a Korean nationwide database, individuals without SSc who underwent national health check-ups in 2009 were selected and followed-up through 2019. Serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride were measured on the health check-up date in 2009. Individuals who developed SSc during follow-up were identified. Multivariable Cox models were performed to estimate the risk of incident SSc according to TC, HDL-C, LDL-C, and triglyceride levels, respectively. Results: Of the 9,894,996 individuals selected, 1355 individuals developed SSc during a mean follow-up of 9.2 years (incidence rate=1.49 per 100,000 person-years). Levels of TC (adjusted hazard ratio [aHR] 0.959, 95% confidence interval [CI] 0.945-0.974), HDL-C (aHR 0.968, 95% CI 0.950-0.987), LDL-C (aHR 0.968, 95% CI 0.952-0.983) were inversely associated with the risk of incident SSc, whereas no significant association was observed between levels of triglyceride (aHR 1.004, 95% CI 0.998-1.011) and risk of incident SSc. Conclusion: Serum levels of TC, HDL-C, and LDL-C were inversely associated with the risk of incident SSc. Our findings provide new insights that altered lipid profile could be considered a non-causal biomarker associated with incident SSc, which could help early diagnosis. The underlying mechanism for this association needs further studies. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CLINICAL EPIDEMIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association Between Lipid Profile and Risk of Incident Systemic Sclerosis: A Nationwide Population-Based Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Oh Chan Kwon | - |
dc.contributor.googleauthor | Kyungdo Han | - |
dc.contributor.googleauthor | Min-Chan Park | - |
dc.identifier.doi | 10.1136/annrheumdis-2023-eular.2532 | - |
dc.contributor.localId | A05818 | - |
dc.contributor.localId | A01470 | - |
dc.relation.journalcode | J04428 | - |
dc.identifier.pmid | 38050603 | - |
dc.subject.keyword | high-density lipoprotein cholesterol | - |
dc.subject.keyword | low-density lipoprotein cholesterol | - |
dc.subject.keyword | risk factor | - |
dc.subject.keyword | systemic sclerosis | - |
dc.subject.keyword | total cholesterol | - |
dc.contributor.alternativeName | Kwon, Oh Chan | - |
dc.contributor.affiliatedAuthor | 권오찬 | - |
dc.contributor.affiliatedAuthor | 박민찬 | - |
dc.citation.volume | 15 | - |
dc.citation.startPage | 1095 | - |
dc.citation.endPage | 1107 | - |
dc.identifier.bibliographicCitation | CLINICAL EPIDEMIOLOGY, Vol.15 : 1095-1107, 2023-11 | - |
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