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A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine
DC Field | Value | Language |
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dc.contributor.author | 김희영 | - |
dc.contributor.author | 이배환 | - |
dc.date.accessioned | 2024-01-03T00:10:49Z | - |
dc.date.available | 2024-01-03T00:10:49Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 1355-6215 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197172 | - |
dc.description.abstract | Administration of cocaine increases synaptic dopamine levels by blocking dopamine reuptake and leads to increased locomotor activity and compulsive drug-seeking behaviour. It has been suggested that the lateral hypothalamus (LH) or lateral habenula (LHb) is involved in drug-seeking behaviours. To explore the role of the LH and the LHb in cocaine-induced psychomotor responses, we tested whether modulation of the LH or the LH-LHb circuit affects cocaine-induced locomotion. Cocaine-induced locomotor activity and dopamine release were suppressed by the activation of the LH with 2-[2,6-difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide (PEPA), an AMPA receptor agonist. When the LH was inhibited by microinjection of a GABA receptor agonists mixture prior to cocaine injection, the cocaine's effects were enhanced. Furthermore, optogenetic activation of the LH-LHb circuit attenuated the cocaine-induced locomotion, while optogenetic inhibition of the LH-LHb circuit increased it. In vivo extracellular recording found that the LH sent a glutamatergic projection to the LHb. These findings suggest that the LH glutamatergic projection to the LHb plays an active role in the modulation of cocaine-induced psychomotor responses. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | ADDICTION BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cocaine* / pharmacology | - |
dc.subject.MESH | Dopamine | - |
dc.subject.MESH | GABA Agonists / pharmacology | - |
dc.subject.MESH | Habenula* | - |
dc.subject.MESH | Hypothalamic Area, Lateral | - |
dc.title | A hypothalamus-habenula circuit regulates psychomotor responses induced by cocaine | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학교실) | - |
dc.contributor.googleauthor | Dan Bi Ahn | - |
dc.contributor.googleauthor | Han Byeol Jang | - |
dc.contributor.googleauthor | Yeonhee Ryu | - |
dc.contributor.googleauthor | Hyung Kyu Kim | - |
dc.contributor.googleauthor | Xiaowei Guan | - |
dc.contributor.googleauthor | Yu Fan | - |
dc.contributor.googleauthor | Bae Hwan Lee | - |
dc.contributor.googleauthor | Hee Young Kim | - |
dc.identifier.doi | 10.1111/adb.13354 | - |
dc.contributor.localId | A06338 | - |
dc.contributor.localId | A02791 | - |
dc.relation.journalcode | J03315 | - |
dc.identifier.eissn | 1369-1600 | - |
dc.identifier.pmid | 38017642 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/adb.13354 | - |
dc.subject.keyword | cocaine behaviour | - |
dc.subject.keyword | lateral habenula | - |
dc.subject.keyword | lateral hypothalamus | - |
dc.subject.keyword | locomotion | - |
dc.subject.keyword | optogenetics | - |
dc.contributor.alternativeName | Kim, Hee Young | - |
dc.contributor.affiliatedAuthor | 김희영 | - |
dc.contributor.affiliatedAuthor | 이배환 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | e13354 | - |
dc.identifier.bibliographicCitation | ADDICTION BIOLOGY, Vol.28(12) : e13354, 2023-12 | - |
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