Cited 3 times in
Changes in the prevalence of pathogens causing hospital-acquired bacterial pneumonia and the impact of their antimicrobial resistance patterns on clinical outcomes: A propensity-score-matched study
DC Field | Value | Language |
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dc.contributor.author | 김도균 | - |
dc.contributor.author | 이경화 | - |
dc.contributor.author | 정석훈 | - |
dc.contributor.author | 조재화 | - |
dc.contributor.author | 최민혁 | - |
dc.date.accessioned | 2023-11-28T03:26:58Z | - |
dc.date.available | 2023-11-28T03:26:58Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 0924-8579 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196812 | - |
dc.description.abstract | Background: This study aimed to evaluate changes in the prevalence of pathogens causing hospital-acquired bacterial pneumonia (HABP) and their antimicrobial resistance patterns in recent years, and to identify risk factors for 28-day all-cause mortality (ACM) in patients with HABP. Methods: A propensity-score-matched study was performed by randomly allocating patients with ventilator-associated and non-ventilator-associated bacterial pneumonia admitted to two university hospitals between 2011 and 2021. Results: In total, 17,250 patients with HABP were enrolled. The annual incidence of Staphylococcus aureus HABP decreased during the study period, while that of Klebsiella pneumoniae HABP increased significantly each year. Over the same period, the resistance rate of S. aureus to methicillin decreased from 88.4% to 64.4%, while the non-susceptibility rate of K. pneumoniae to carbapenems increased from 0% to 38%. HABP caused by A. baumannii [adjusted odds ratio (aOR) 1.50, 95% confidence interval (CI) 1.25-1.79], K. pneumoniae (aOR 1.28, 95% CI 1.16-1.40) and Stenotrophomonas maltophilia (aOR 1.32, 95% CI 1.05-1.66) was a risk factor for 28-day ACM. Patients with HABP caused by methicillin-resistant S. aureus and carbapenem-non-susceptible A. baumannii or K. pneumoniae had a significantly lower probability of survival. HABP with preceding coronavirus disease 2019 (COVID-19) was associated with high 28-day ACM (aOR 5.40, 955 CI 3.03-9.64) and high incidence of bacteraemic pneumonia (aOR 40.55, 95% CI 5.26-312.79). Conclusions: This study showed shifting trends in HABP-causing pathogens in terms of annual incidence and resistance rates to major therapeutic antimicrobial agents. HABP-causing bacterial pathogens, their antimicrobial resistance phenotypes, and preceding COVID-19 were significantly associated with progression of HABP to bloodstream infection and 28-day ACM in infected patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Publishers | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anti-Bacterial Agents / pharmacology | - |
dc.subject.MESH | Anti-Bacterial Agents / therapeutic use | - |
dc.subject.MESH | Anti-Infective Agents* / therapeutic use | - |
dc.subject.MESH | Bacteria | - |
dc.subject.MESH | COVID-19* | - |
dc.subject.MESH | Cross Infection* / drug therapy | - |
dc.subject.MESH | Cross Infection* / epidemiology | - |
dc.subject.MESH | Cross Infection* / microbiology | - |
dc.subject.MESH | Drug Resistance, Bacterial | - |
dc.subject.MESH | Healthcare-Associated Pneumonia* / drug therapy | - |
dc.subject.MESH | Hospitals | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Klebsiella pneumoniae | - |
dc.subject.MESH | Methicillin-Resistant Staphylococcus aureus* | - |
dc.subject.MESH | Pneumonia, Bacterial* / drug therapy | - |
dc.subject.MESH | Pneumonia, Bacterial* / epidemiology | - |
dc.subject.MESH | Pneumonia, Bacterial* / microbiology | - |
dc.subject.MESH | Pneumonia, Ventilator-Associated* / drug therapy | - |
dc.subject.MESH | Pneumonia, Ventilator-Associated* / epidemiology | - |
dc.subject.MESH | Pneumonia, Ventilator-Associated* / microbiology | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Staphylococcus aureus | - |
dc.title | Changes in the prevalence of pathogens causing hospital-acquired bacterial pneumonia and the impact of their antimicrobial resistance patterns on clinical outcomes: A propensity-score-matched study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Min Hyuk Choi | - |
dc.contributor.googleauthor | Dokyun Kim | - |
dc.contributor.googleauthor | Kyoung Hwa Lee | - |
dc.contributor.googleauthor | Jae Hwa Cho | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.identifier.doi | 10.1016/j.ijantimicag.2023.106886 | - |
dc.contributor.localId | A04891 | - |
dc.contributor.localId | A04620 | - |
dc.contributor.localId | A03619 | - |
dc.contributor.localId | A05674 | - |
dc.relation.journalcode | J01088 | - |
dc.identifier.eissn | 1872-7913 | - |
dc.identifier.pmid | 37343808 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0924857923001656 | - |
dc.subject.keyword | Bacteraemic pneumonia | - |
dc.subject.keyword | COVID-19 | - |
dc.subject.keyword | Hospital-acquired pneumonia | - |
dc.subject.keyword | Mortality | - |
dc.subject.keyword | Ventilator-associated pneumonia | - |
dc.contributor.alternativeName | Kim, Dokyun | - |
dc.contributor.affiliatedAuthor | 김도균 | - |
dc.contributor.affiliatedAuthor | 이경화 | - |
dc.contributor.affiliatedAuthor | 정석훈 | - |
dc.contributor.affiliatedAuthor | 조재화 | - |
dc.citation.volume | 62 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 106886 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, Vol.62(3) : 106886, 2023-09 | - |
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