Cited 2 times in
The effects of perioperative dexmedetomidine infusion on hemodynamic stability during laparoscopic adrenalectomy for pheochromocytoma: a randomized study
DC Field | Value | Language |
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dc.contributor.author | 강상욱 | - |
dc.contributor.author | 김나영 | - |
dc.contributor.author | 문지애 | - |
dc.contributor.author | 유영철 | - |
dc.contributor.author | 김영원 | - |
dc.date.accessioned | 2023-11-28T03:26:28Z | - |
dc.date.available | 2023-11-28T03:26:28Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196809 | - |
dc.description.abstract | Introduction: Pheochromocytoma is a rare catecholamine-producing neuroendocrine tumor originating from the adrenal medulla chromaffin cells. Hemodynamic instability can occur during the induction of anesthesia and surgical manipulation of the tumor. This study investigated the effects of intraoperative dexmedetomidine administration on hemodynamic stability in patients undergoing laparoscopic adrenalectomy for pheochromocytoma. Methods: Forty patients who underwent laparoscopic adrenalectomy for pheochromocytoma were randomly assigned to the dexmedetomidine (n = 20) or control (n = 20) group. The primary outcome of this study was intraoperative hemodynamic stability, and the secondary endpoint was the plasma catecholamine concentrations, specifically of epinephrine and norepinephrine. Results: The intraoperative maximum blood pressures were significantly lower in the dexmedetomidine group (control vs. dexmedetomidine group: 182 ± 31 vs. 161 ± 20, 102 ± 17 vs. 90 ± 10, and 128 ± 22 vs. 116 ± 12 [mean ± SD] mmHg and p = 0.020, 0.015, and 0.040 for systolic, diastolic, and mean blood pressure, respectively). The maximum heart rate during surgery was 108 ± 15 bpm in the control group and 95 ± 12 bpm in the dexmedetomidine group (p = 0.010). Other parameters of hemodynamic instability were comparable between both groups. Plasma catecholamine concentrations did not differ between the groups. Conclusion: Dexmedetomidine infusion following the induction of anesthesia at a rate of 0.5 μg/kg/h significantly attenuated the maximum intraoperative SBP, DBP, MBP, and HR, contributing to improved hemodynamic stability. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Media S.A. | - |
dc.relation.isPartOf | FRONTIERS IN MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The effects of perioperative dexmedetomidine infusion on hemodynamic stability during laparoscopic adrenalectomy for pheochromocytoma: a randomized study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Youngwon Kim | - |
dc.contributor.googleauthor | Young Chul Yoo | - |
dc.contributor.googleauthor | Na Young Kim | - |
dc.contributor.googleauthor | Hye Jung Shin | - |
dc.contributor.googleauthor | Ki Hong Kweon | - |
dc.contributor.googleauthor | Jiae Moon | - |
dc.contributor.googleauthor | Sang-Wook Kang | - |
dc.identifier.doi | 10.3389/fmed.2023.1276535 | - |
dc.contributor.localId | A00032 | - |
dc.contributor.localId | A00348 | - |
dc.contributor.localId | A06073 | - |
dc.contributor.localId | A02484 | - |
dc.relation.journalcode | J03762 | - |
dc.identifier.eissn | 2296-858X | - |
dc.contributor.alternativeName | Kang, Sang Wook | - |
dc.contributor.affiliatedAuthor | 강상욱 | - |
dc.contributor.affiliatedAuthor | 김나영 | - |
dc.contributor.affiliatedAuthor | 문지애 | - |
dc.contributor.affiliatedAuthor | 유영철 | - |
dc.citation.volume | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN MEDICINE, Vol.10 : 1-9, 2023-11 | - |
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