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High pretransplant FGF23 level is associated with persistent vitamin D insufficiency and poor graft survival in kidney transplant patients

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dc.contributor.author양재석-
dc.contributor.author허규하-
dc.date.accessioned2023-11-28T03:18:37Z-
dc.date.available2023-11-28T03:18:37Z-
dc.date.issued2023-11-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/196783-
dc.description.abstractVitamin D3 (25[OH]D3) insufficiency and fibroblast growth factor 23 (FGF23) elevation are usually attenuated after kidney transplantation (KT). However, elevated FGF23 may be associated with poor graft outcomes and vitamin D insufficiency after KT. This study investigated the effect of pretransplant FGF23 levels on post-KT 25(OH)D3 status and graft outcomes. Serum FGF23 levels from 400 participants of the KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation were measured. Annual serum 25(OH)D3 levels, all-cause mortality, cardiovascular event, and graft survival were assessed according to baseline FGF23 levels. Serum 25(OH)D3 levels were initially increased 1 year after KT (12.6 ± 7.4 vs. 22.6 ± 6.4 ng/mL). However, the prevalence of post-KT vitamin D deficiency increased again after post-KT 3 years (79.1% at baseline, 30.8% and 37.8% at 3 and 6 years, respectively). Serum FGF23 level was decreased 3 years post-KT. When participants were categorized into tertiles according to baseline FGF23 level (low, middle, high), 25(OH)D3 level in the low FGF23 group was persistently low at a median follow-up of 8.3 years. Furthermore, high baseline FGF23 level was a risk factor for poor graft survival (HR 5.882, 95% C.I.; 1.443-23.976, P = 0.013). Elevated FGF23 levels are associated with persistently low post-transplant vitamin D levels and poor graft survival.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHCohort Studies-
dc.subject.MESHFibroblast Growth Factors-
dc.subject.MESHGraft Survival-
dc.subject.MESHHumans-
dc.subject.MESHKidney Transplantation*-
dc.subject.MESHVitamin D-
dc.subject.MESHVitamin D Deficiency*-
dc.subject.MESHVitamins-
dc.titleHigh pretransplant FGF23 level is associated with persistent vitamin D insufficiency and poor graft survival in kidney transplant patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJung-Hwa Ryu-
dc.contributor.googleauthorHee Jung Jeon-
dc.contributor.googleauthorRo Han-
dc.contributor.googleauthorHee-Yeon Jung-
dc.contributor.googleauthorMyung-Gyu Kim-
dc.contributor.googleauthorKyu Ha Huh-
dc.contributor.googleauthorJae Berm Park-
dc.contributor.googleauthorKyung Pyo Kang-
dc.contributor.googleauthorSeungyeup Han-
dc.contributor.googleauthorJaeseok Yang-
dc.identifier.doi10.1038/s41598-023-46889-0-
dc.contributor.localIdA06130-
dc.contributor.localIdA04344-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid37949967-
dc.contributor.alternativeNameYang, Jaeseok-
dc.contributor.affiliatedAuthor양재석-
dc.contributor.affiliatedAuthor허규하-
dc.citation.volume13-
dc.citation.number1-
dc.citation.startPage19640-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.13(1) : 19640, 2023-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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