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High pretransplant FGF23 level is associated with persistent vitamin D insufficiency and poor graft survival in kidney transplant patients
DC Field | Value | Language |
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dc.contributor.author | 양재석 | - |
dc.contributor.author | 허규하 | - |
dc.date.accessioned | 2023-11-28T03:18:37Z | - |
dc.date.available | 2023-11-28T03:18:37Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196783 | - |
dc.description.abstract | Vitamin D3 (25[OH]D3) insufficiency and fibroblast growth factor 23 (FGF23) elevation are usually attenuated after kidney transplantation (KT). However, elevated FGF23 may be associated with poor graft outcomes and vitamin D insufficiency after KT. This study investigated the effect of pretransplant FGF23 levels on post-KT 25(OH)D3 status and graft outcomes. Serum FGF23 levels from 400 participants of the KoreaN Cohort Study for Outcome in Patients With Kidney Transplantation were measured. Annual serum 25(OH)D3 levels, all-cause mortality, cardiovascular event, and graft survival were assessed according to baseline FGF23 levels. Serum 25(OH)D3 levels were initially increased 1 year after KT (12.6 ± 7.4 vs. 22.6 ± 6.4 ng/mL). However, the prevalence of post-KT vitamin D deficiency increased again after post-KT 3 years (79.1% at baseline, 30.8% and 37.8% at 3 and 6 years, respectively). Serum FGF23 level was decreased 3 years post-KT. When participants were categorized into tertiles according to baseline FGF23 level (low, middle, high), 25(OH)D3 level in the low FGF23 group was persistently low at a median follow-up of 8.3 years. Furthermore, high baseline FGF23 level was a risk factor for poor graft survival (HR 5.882, 95% C.I.; 1.443-23.976, P = 0.013). Elevated FGF23 levels are associated with persistently low post-transplant vitamin D levels and poor graft survival. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Fibroblast Growth Factors | - |
dc.subject.MESH | Graft Survival | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Transplantation* | - |
dc.subject.MESH | Vitamin D | - |
dc.subject.MESH | Vitamin D Deficiency* | - |
dc.subject.MESH | Vitamins | - |
dc.title | High pretransplant FGF23 level is associated with persistent vitamin D insufficiency and poor graft survival in kidney transplant patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jung-Hwa Ryu | - |
dc.contributor.googleauthor | Hee Jung Jeon | - |
dc.contributor.googleauthor | Ro Han | - |
dc.contributor.googleauthor | Hee-Yeon Jung | - |
dc.contributor.googleauthor | Myung-Gyu Kim | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.contributor.googleauthor | Jae Berm Park | - |
dc.contributor.googleauthor | Kyung Pyo Kang | - |
dc.contributor.googleauthor | Seungyeup Han | - |
dc.contributor.googleauthor | Jaeseok Yang | - |
dc.identifier.doi | 10.1038/s41598-023-46889-0 | - |
dc.contributor.localId | A06130 | - |
dc.contributor.localId | A04344 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 37949967 | - |
dc.contributor.alternativeName | Yang, Jaeseok | - |
dc.contributor.affiliatedAuthor | 양재석 | - |
dc.contributor.affiliatedAuthor | 허규하 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 19640 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.13(1) : 19640, 2023-11 | - |
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