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The Effect of Model for End-Stage Liver Disease 3.0 on Disparities between Patients with and without Hepatocellular Carcinoma in Korea
DC Field | Value | Language |
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dc.contributor.author | 김덕기 | - |
dc.contributor.author | 이재근 | - |
dc.contributor.author | 이혜원 | - |
dc.contributor.author | 주동진 | - |
dc.date.accessioned | 2023-11-28T03:15:30Z | - |
dc.date.available | 2023-11-28T03:15:30Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196771 | - |
dc.description.abstract | Purpose: The model for end-stage liver disease (MELD) 3.0 has recently been suggested for determining liver allocation. We aimed to apply MELD 3.0 to a Korean population and to discover differences between patients with and without hepatocellular carcinoma (HCC). Materials and methods: This study is a retrospective study of 2203 patients diagnosed with liver cirrhosis at Severance Hospital between 2016-2022. Harrell's concordance index was used to validate the ability of MELD scores to predict 90-day survival. Results: During a mean follow-up of 12.9 months, 90-day survival was 61.9% in all patients, 50.4% in the HCC patients, and 74.8% in the non-HCC patients. Within the HCC patients, the concordance index for patients on the waitlist was 0.653 using MELD, which increased to 0.753 using MELD 3.0. Among waitlisted patients, the 90-day survival of HCC patients was worse than that of non-HCC patients with MELD scores of 31-37 only (69.7% vs. 30.0%, p=0.001). Applying MELD 3.0, the 90-day survival of HCC patients was worse than that of non-HCC patients across a wider range of MELD 3.0 scores, compared to MELD, with MELD 3.0 scores of 21-30 and 31-37 (82.0% vs. 72.5% and 72.3% vs. 24.3%, p=0.02 and p<0.001, respectively). Conclusion: MELD 3.0 predicted 90-day survival of the HCC patients more accurately than original MELD score; however, the disparity between HCC and non-HCC patients increased, particularly in patients with MELD scores of 21-30. Therefore, a novel exception score is needed or the current exception score system should be modified. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Carcinoma, Hepatocellular* / diagnosis | - |
dc.subject.MESH | End Stage Liver Disease* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms* / pathology | - |
dc.subject.MESH | Liver Transplantation* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.title | The Effect of Model for End-Stage Liver Disease 3.0 on Disparities between Patients with and without Hepatocellular Carcinoma in Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Kunhee Kim | - |
dc.contributor.googleauthor | Deok-Gie Kim | - |
dc.contributor.googleauthor | Jae Geun Lee | - |
dc.contributor.googleauthor | Dong Jin Joo | - |
dc.contributor.googleauthor | Hye Won Lee | - |
dc.identifier.doi | 10.3349/ymj.2023.0163 | - |
dc.contributor.localId | A05303 | - |
dc.contributor.localId | A03068 | - |
dc.contributor.localId | A03318 | - |
dc.contributor.localId | A03948 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 37880845 | - |
dc.subject.keyword | MELD 3.0 | - |
dc.subject.keyword | MELD score | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | liver cirrhosis | - |
dc.contributor.alternativeName | Kim, Deok Gie | - |
dc.contributor.affiliatedAuthor | 김덕기 | - |
dc.contributor.affiliatedAuthor | 이재근 | - |
dc.contributor.affiliatedAuthor | 이혜원 | - |
dc.contributor.affiliatedAuthor | 주동진 | - |
dc.citation.volume | 64 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 647 | - |
dc.citation.endPage | 657 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.64(11) : 647-657, 2023-11 | - |
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