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Altered prefrontal beta oscillatory activity during removal of information from working memory in obsessive-compulsive disorder

Authors
 Young Jun Boo  ;  Do-Won Kim  ;  Jin Young Park  ;  Bong Soo Kim  ;  Jin Woo Chang  ;  Jee In Kang  ;  Se Joo Kim 
Citation
 BMC PSYCHIATRY, Vol.23(1) : 645, 2023-09 
Journal Title
BMC PSYCHIATRY
Issue Date
2023-09
MeSH
Case-Control Studies ; Cognition ; Humans ; Memory Disorders ; Memory, Short-Term* ; Obsessive-Compulsive Disorder*
Keywords
Beta oscillations ; Delayed matching-to-sample task ; Magnetoencephalography ; Obsessive-compulsive disorder ; Removal of information ; Working memory
Abstract
Background: Obsessive-compulsive disorder (OCD) is related to working memory impairment. Since patients with OCD have difficulty controlling their obsessive thoughts, removal of irrelevant information might be important in the pathophysiology of OCD. However, little is known about brain activity during the removal of information from working memory in patients with OCD. Our goal was to explore potential deficits in inhibitory function related to working memory processes in patients with OCD.

Methods: Sixteen OCD patients and 20 healthy controls (HCs) were recruited. We compared in prefrontal alpha and beta band activity derived from magnetoencephalography (MEG) between patients with OCD and HCs during multiple phases of information processing associated with working memory, especially in post-trial period of the visuospatial working memory task (the delayed matching-to-sample task), which is presumed to be related to the information removal process of working memory.

Results: Prefrontal post-trial beta power change (presumed to occur at high levels during the post-trial period) exhibited significant reductions in patients with OCD compared to HCs. In addition, the post-trial beta power change was negatively correlated with Obsessive-Compulsive Inventory-Revised total scores in patients with OCD.

Conclusions: These findings suggest that impairment in the removal of information from working memory might be a key mechanism underlying the inability of OCD patients to rid themselves of their obsessions.
Files in This Item:
T202306263.pdf Download
DOI
10.1186/s12888-023-05149-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Park, Jin Young(박진영) ORCID logo https://orcid.org/0000-0002-5351-9549
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196762
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