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Subtypes of Patients with Mild to Moderate Airflow Limitation as Predictors of Chronic Obstructive Pulmonary Disease Exacerbation
DC Field | Value | Language |
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dc.contributor.author | 정지예 | - |
dc.date.accessioned | 2023-11-28T03:13:30Z | - |
dc.date.available | 2023-11-28T03:13:30Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196760 | - |
dc.description.abstract | COPD is a heterogeneous disease, and its acute exacerbation is a major prognostic factor. We used cluster analysis to predict COPD exacerbation due to subtypes of mild-moderate airflow limitation. In all, 924 patients from the Korea COPD Subgroup Study cohort, with a forced expiratory volume (FEV1) ≥ 50% and documented age, body mass index (BMI), smoking status, smoking pack-years, COPD assessment test (CAT) score, predicted post-bronchodilator FEV1, were enrolled. Four groups, putative chronic bronchitis (n = 224), emphysema (n = 235), young smokers (n = 248), and near normal (n = 217), were identified. The chronic bronchitis group had the highest BMI, and the one with emphysema had the oldest age, lowest BMI, and highest smoking pack-years. The young smokers group had the youngest age and the highest proportion of current smokers. The near-normal group had the highest proportion of never-smokers and near-normal lung function. When compared with the near-normal group, the emphysema group had a higher risk of acute exacerbation (OR: 1.93, 95% CI: 1.29-2.88). However, multiple logistic regression showed that chronic bronchitis (OR: 2.887, 95% CI: 1.065-8.192), predicted functional residual capacity (OR: 1.023, 95% CI: 1.007-1.040), fibrinogen (OR: 1.004, 95% CI: 1.001-1.008), and gastroesophageal reflux disease were independent predictors of exacerbation (OR: 2.646, 95% CI: 1.142-6.181). The exacerbation-susceptible subtypes require more aggressive prevention strategies. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Subtypes of Patients with Mild to Moderate Airflow Limitation as Predictors of Chronic Obstructive Pulmonary Disease Exacerbation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Nam Eun Kim | - |
dc.contributor.googleauthor | Eun-Hwa Kang | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.contributor.googleauthor | Chang Youl Lee | - |
dc.contributor.googleauthor | Won Yeon Lee | - |
dc.contributor.googleauthor | Seong Yong Lim | - |
dc.contributor.googleauthor | Dong Il Park | - |
dc.contributor.googleauthor | Kwang Ha Yoo | - |
dc.contributor.googleauthor | Ki-Suck Jung | - |
dc.contributor.googleauthor | Jin Hwa Lee | - |
dc.identifier.doi | 10.3390/jcm12206643 | - |
dc.contributor.localId | A03735 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 37892781 | - |
dc.subject.keyword | acute exacerbation | - |
dc.subject.keyword | k-means clustering | - |
dc.subject.keyword | multicenter observation cohort study | - |
dc.subject.keyword | subtypes of COPD | - |
dc.contributor.alternativeName | Jung, Ji Ye | - |
dc.contributor.affiliatedAuthor | 정지예 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 6643 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.12(20) : 6643, 2023-10 | - |
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