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On-demand Versus Continuous Maintenance Treatment With a Proton Pump Inhibitor for Mild Gastroesophageal Reflux Disease: A Prospective Randomized Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | 윤영훈 | - |
dc.contributor.author | 정다현 | - |
dc.contributor.author | 허철웅 | - |
dc.contributor.author | 김희만 | - |
dc.date.accessioned | 2023-11-07T08:14:42Z | - |
dc.date.available | 2023-11-07T08:14:42Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 2093-0879 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196621 | - |
dc.description.abstract | Background/aims: It remains unclear which maintenance treatment modality is most appropriate for mild gastroesophageal reflux disease (GERD). We aimed to compare on-demand treatment with continuous treatment using a proton pump inhibitor (PPI) in the maintenance treatment for patients with non-erosive GERD or mild erosive esophagitis. Methods: Patients whose GERD symptoms improved after 4 weeks of standard dose PPI treatment were prospectively enrolled at 25 hospitals. Subsequently, the enrolled patients were randomly assigned to either an on-demand or a continuous maintenance treatment group, and followed in an 8-week interval for up to 24 weeks. Results: A total of 304 patients were randomized to maintenance treatment (continuous, n = 151 vs on-demand, n = 153). The primary outcome, the overall proportion of unwillingness to continue the assigned maintenance treatment modality, failed to confirm the non-inferiority of on-demand treatment (45.9%) compared to continuous treatment (36.1%). Compared with the on-demand group, the GERD symptom and health-related quality of life scores significantly more improved and the overall satisfaction score was significantly higher in the continuous treatment group, particularly at week 8 and week 16 of maintenance treatment. Work impairment scores were not different in the 2 groups, but the prescription cost was less in the on-demand group. Serum gastrin levels significantly elevated in the continuous treatment group, but not in the on-demand group. Conclusions: Continuous treatment seems to be more appropriate for the initial maintenance treatment of non-erosive GERD or mild erosive esophagitis than on-demand treatment. Stepping down to on-demand treatment needs to be considered after a sufficient period of continuous treatment. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | Korean Society of Neurogastroenterology and Motility | - |
dc.relation.isPartOf | JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | On-demand Versus Continuous Maintenance Treatment With a Proton Pump Inhibitor for Mild Gastroesophageal Reflux Disease: A Prospective Randomized Multicenter Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Da Hyun Jung | - |
dc.contributor.googleauthor | Young Hoon Youn | - |
dc.contributor.googleauthor | Hye-Kyung Jung | - |
dc.contributor.googleauthor | Seung Young Kim | - |
dc.contributor.googleauthor | Cheal Wung Huh | - |
dc.contributor.googleauthor | Cheol Min Shin | - |
dc.contributor.googleauthor | Jung-Hwan Oh | - |
dc.contributor.googleauthor | Kyu Chan Huh | - |
dc.contributor.googleauthor | Moo In Park | - |
dc.contributor.googleauthor | Suck Chei Choi | - |
dc.contributor.googleauthor | Ki Bae Kim | - |
dc.contributor.googleauthor | Seon-Young Park | - |
dc.contributor.googleauthor | Joong Goo Kwon | - |
dc.contributor.googleauthor | Yu Kyung Cho | - |
dc.contributor.googleauthor | Jung Ho Park | - |
dc.contributor.googleauthor | Jeong Eun Shin | - |
dc.contributor.googleauthor | Eun Jeong Gong | - |
dc.contributor.googleauthor | Jae Hak Kim | - |
dc.contributor.googleauthor | Su Jin Hong | - |
dc.contributor.googleauthor | Hyun Jin Kim | - |
dc.contributor.googleauthor | Sam Ryong Jee | - |
dc.contributor.googleauthor | Ju Yup Lee | - |
dc.contributor.googleauthor | Kee Wook Jung | - |
dc.contributor.googleauthor | Hee Man Kim | - |
dc.contributor.googleauthor | Kwang Jae Lee | - |
dc.identifier.doi | 10.5056/jnm23130 | - |
dc.contributor.localId | A02583 | - |
dc.contributor.localId | A03591 | - |
dc.contributor.localId | A05070 | - |
dc.relation.journalcode | J01623 | - |
dc.identifier.eissn | 2093-0887 | - |
dc.identifier.pmid | 37814436 | - |
dc.subject.keyword | Gastroesophageal reflux | - |
dc.subject.keyword | Maintenance | - |
dc.subject.keyword | Proton pump inhibitors | - |
dc.contributor.alternativeName | Youn, Young Hoon | - |
dc.contributor.affiliatedAuthor | 윤영훈 | - |
dc.contributor.affiliatedAuthor | 정다현 | - |
dc.contributor.affiliatedAuthor | 허철웅 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 460 | - |
dc.citation.endPage | 469 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, Vol.29(4) : 460-469, 2023-10 | - |
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