Cited 2 times in
A new index for distinguishing hypereosinophilic syndrome and antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박용범 | - |
dc.contributor.author | 박중원 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 유주영 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 이재현 | - |
dc.date.accessioned | 2023-11-07T07:59:27Z | - |
dc.date.available | 2023-11-07T07:59:27Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 0125-877X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196566 | - |
dc.description.abstract | Background: It is difficult to differentiate between hypereosinophilic syndrome (HES) and antineutrophil cytoplasmic antibody (ANCA)-negative eosinophilic granulomatosis with polyangiitis (EGPA). Objective: We compared laboratory data at diagnosis between Korean patients with HES and ANCA-negative EGPA and investigated independent laboratory predictors suggesting HES. Methods: We reviewed the medical records of 41 HES patients and 16 ANCA-negative EGPA patients. The cut-offs were extrapolated by the receiver operator characteristic (ROC) curve. The odds ratio (OR) and relative risk (RR) were assessed using the multivariable logistic regression analysis and the chi-square test, respectively. We developed a new equation by assigning a weight to each variable according to the slopes (B) and expressed a decimal as the nearest integer. Results: HES patients had a higher median WBC and eosinophil counts than ANCA-negative EGPA patients. The cutoffs of WBC and eosinophil counts for HES were set at 9,900.0/mm3 and 2,400.0/mm3. In the multivariable analysis, WBC count ≥ 9,900.0/mm3 (B 1.763) and eosinophil count ≥ 2,400.0/mm3 (B 1.515) were significantly associated with HES. An equation was as follows: HES-suggesting laboratory index (HSLI) = 2 × (WBC count ≥ 9,900.0/mm3 (1 = No or 2 = Yes)) + 1.5 × (eosinophil count ≥ 2,400.0/mm3 (1 = No or 2 = Yes)). The cut-off of HSLI for HES was 4.25. Patients with HSLI ≥ 4.25 exhibited a significantly high RR (51.429) for HES, compared to those without. Conclusions: In conclusion, the cut-off of HSLI derived from WBC and eosinophil counts could be an independent predictor of HES in patients suspected of both HES and ANCA-negative EGPA. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Allergy and Immunology Society of Thailand | - |
dc.relation.isPartOf | ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antibodies, Antineutrophil Cytoplasmic | - |
dc.subject.MESH | Churg-Strauss Syndrome* / diagnosis | - |
dc.subject.MESH | Eosinophils | - |
dc.subject.MESH | Granulomatosis with Polyangiitis* / diagnosis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypereosinophilic Syndrome* / diagnosis | - |
dc.title | A new index for distinguishing hypereosinophilic syndrome and antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | Juyoung Yoo | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Jung-Won Park | - |
dc.contributor.googleauthor | Jae-Hyun Lee | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.identifier.doi | 10.12932/ap-080420-0805 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A01681 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A05157 | - |
dc.contributor.localId | A02824 | - |
dc.contributor.localId | A03086 | - |
dc.relation.journalcode | J03115 | - |
dc.identifier.pmid | 33068368 | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | 박용범 | - |
dc.contributor.affiliatedAuthor | 박중원 | - |
dc.contributor.affiliatedAuthor | 안성수 | - |
dc.contributor.affiliatedAuthor | 유주영 | - |
dc.contributor.affiliatedAuthor | 이상원 | - |
dc.contributor.affiliatedAuthor | 이재현 | - |
dc.citation.volume | 41 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 244 | - |
dc.citation.endPage | 252 | - |
dc.identifier.bibliographicCitation | ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, Vol.41(3) : 244-252, 2023-09 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.