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A new index for distinguishing hypereosinophilic syndrome and antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis

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dc.contributor.author박용범-
dc.contributor.author박중원-
dc.contributor.author안성수-
dc.contributor.author유주영-
dc.contributor.author이상원-
dc.contributor.author이재현-
dc.date.accessioned2023-11-07T07:59:27Z-
dc.date.available2023-11-07T07:59:27Z-
dc.date.issued2023-09-
dc.identifier.issn0125-877X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/196566-
dc.description.abstractBackground: It is difficult to differentiate between hypereosinophilic syndrome (HES) and antineutrophil cytoplasmic antibody (ANCA)-negative eosinophilic granulomatosis with polyangiitis (EGPA). Objective: We compared laboratory data at diagnosis between Korean patients with HES and ANCA-negative EGPA and investigated independent laboratory predictors suggesting HES. Methods: We reviewed the medical records of 41 HES patients and 16 ANCA-negative EGPA patients. The cut-offs were extrapolated by the receiver operator characteristic (ROC) curve. The odds ratio (OR) and relative risk (RR) were assessed using the multivariable logistic regression analysis and the chi-square test, respectively. We developed a new equation by assigning a weight to each variable according to the slopes (B) and expressed a decimal as the nearest integer. Results: HES patients had a higher median WBC and eosinophil counts than ANCA-negative EGPA patients. The cutoffs of WBC and eosinophil counts for HES were set at 9,900.0/mm3 and 2,400.0/mm3. In the multivariable analysis, WBC count ≥ 9,900.0/mm3 (B 1.763) and eosinophil count ≥ 2,400.0/mm3 (B 1.515) were significantly associated with HES. An equation was as follows: HES-suggesting laboratory index (HSLI) = 2 × (WBC count ≥ 9,900.0/mm3 (1 = No or 2 = Yes)) + 1.5 × (eosinophil count ≥ 2,400.0/mm3 (1 = No or 2 = Yes)). The cut-off of HSLI for HES was 4.25. Patients with HSLI ≥ 4.25 exhibited a significantly high RR (51.429) for HES, compared to those without. Conclusions: In conclusion, the cut-off of HSLI derived from WBC and eosinophil counts could be an independent predictor of HES in patients suspected of both HES and ANCA-negative EGPA.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAllergy and Immunology Society of Thailand-
dc.relation.isPartOfASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAntibodies, Antineutrophil Cytoplasmic-
dc.subject.MESHChurg-Strauss Syndrome* / diagnosis-
dc.subject.MESHEosinophils-
dc.subject.MESHGranulomatosis with Polyangiitis* / diagnosis-
dc.subject.MESHHumans-
dc.subject.MESHHypereosinophilic Syndrome* / diagnosis-
dc.titleA new index for distinguishing hypereosinophilic syndrome and antineutrophil cytoplasmic antibody-negative eosinophilic granulomatosis with polyangiitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorJuyoung Yoo-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorJung-Won Park-
dc.contributor.googleauthorJae-Hyun Lee-
dc.contributor.googleauthorSang-Won Lee-
dc.identifier.doi10.12932/ap-080420-0805-
dc.contributor.localIdA01579-
dc.contributor.localIdA01681-
dc.contributor.localIdA02233-
dc.contributor.localIdA05157-
dc.contributor.localIdA02824-
dc.contributor.localIdA03086-
dc.relation.journalcodeJ03115-
dc.identifier.pmid33068368-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor박중원-
dc.contributor.affiliatedAuthor안성수-
dc.contributor.affiliatedAuthor유주영-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor이재현-
dc.citation.volume41-
dc.citation.number3-
dc.citation.startPage244-
dc.citation.endPage252-
dc.identifier.bibliographicCitationASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, Vol.41(3) : 244-252, 2023-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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