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Evaluating anti-thymocyte globulin induction doses for better allograft and patient survival in Asian kidney transplant recipients
DC Field | Value | Language |
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dc.contributor.author | 김명수 | - |
dc.contributor.author | 양재석 | - |
dc.date.accessioned | 2023-11-07T07:51:02Z | - |
dc.date.available | 2023-11-07T07:51:02Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196536 | - |
dc.description.abstract | Anti-thymocyte globulin (ATG) is currently the most widely prescribed induction regimen for preventing acute rejection after solid organ transplantation. However, the optimal dose of ATG induction regimen in Asian kidney recipients is unclear. Using the Korean Organ Transplantation Registry, we performed a retrospective cohort study of 4579 adult patients who received renal transplantation in South Korea and divided them into three groups according to the induction regimen: basiliximab group (n = 3655), low-dose ATG group (≤ 4.5 mg/kg; n = 467), and high-dose ATG group (> 4.5 mg/kg; n = 457). We applied the Toolkit for Weighting and Analysis of Nonequivalent Groups (TWANG) package to generate high-quality propensity score weights for intergroup comparisons. During four-year follow-ups, the high-dose ATG group had the highest biopsy-proven acute rejection rate (basiliximab 20.8% vs. low-dose ATG 22.4% vs. high-dose ATG 25.6%; P < 0.001). However, the rates of overall graft failure (4.0% vs. 5.0% vs. 2.6%; P < 0.001) and mortality (1.7% vs. 2.8% vs. 1.0%; P < 0.001) were the lowest in the high-dose ATG group. Our results show that high-dose ATG induction (> 4.5 mg/kg) was superior to basiliximab and low-dose ATG induction in terms of graft and patient survival in Asian patients undergoing kidney transplant. © 2023. The Author(s). | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Allografts | - |
dc.subject.MESH | Antibodies, Monoclonal | - |
dc.subject.MESH | Antilymphocyte Serum* | - |
dc.subject.MESH | Basiliximab | - |
dc.subject.MESH | Graft Rejection / prevention & control | - |
dc.subject.MESH | Graft Survival | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents / therapeutic use | - |
dc.subject.MESH | Kidney Transplantation* / methods | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Evaluating anti-thymocyte globulin induction doses for better allograft and patient survival in Asian kidney transplant recipients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Ye Eun Shim | - |
dc.contributor.googleauthor | Youngmin Ko | - |
dc.contributor.googleauthor | Jung Pyo Lee | - |
dc.contributor.googleauthor | Jin Seok Jeon | - |
dc.contributor.googleauthor | Heungman Jun | - |
dc.contributor.googleauthor | Jaeseok Yang | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Seong Jun Lim | - |
dc.contributor.googleauthor | Hye Eun Kwon | - |
dc.contributor.googleauthor | Joo Hee Jung | - |
dc.contributor.googleauthor | Hyunwook Kwon | - |
dc.contributor.googleauthor | Young Hoon Kim | - |
dc.contributor.googleauthor | Jungbok Lee | - |
dc.contributor.googleauthor | Sung Shin | - |
dc.contributor.googleauthor | Korean Organ Transplantation Registry (KOTRY) study group | - |
dc.identifier.doi | 10.1038/s41598-023-39353-6 | - |
dc.contributor.localId | A00424 | - |
dc.contributor.localId | A06130 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 37532735 | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.affiliatedAuthor | 김명수 | - |
dc.contributor.affiliatedAuthor | 양재석 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 12560 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.13(1) : 12560, 2023-08 | - |
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