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A randomized trial of genotype-guided perindopril use
DC Field | Value | Language |
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dc.contributor.author | 이상학 | - |
dc.contributor.author | 이찬주 | - |
dc.date.accessioned | 2023-11-07T07:50:51Z | - |
dc.date.available | 2023-11-07T07:50:51Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 0263-6352 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196534 | - |
dc.description.abstract | Objective: Cough caused by angiotensin-converting enzyme inhibitors (ACEIs) limits their clinical application and cardiovascular benefits. This randomized trial investigated whether genotype-guided perindopril use could reduce drug-related cough in 20 to 79-year-old individuals with hypertension. Methods: After screening 120 patients and randomization, 68 were assigned to genotyping ( n = 41) and control ( n = 27) groups. NELL1 p.Arg382Trp (rs8176786) and intron (rs10766756) genotype information was used to subdivide the genotyping group into high-risk and low-risk subgroups with at least one or no risk alleles for ACEI-related cough, respectively. The high-risk subgroup received candesartan (8 mg/day) for 6 weeks, whereas the low-risk subgroup received perindopril (4 mg/day). The control group, which was not genotyped, received perindopril (4 mg/day). The primary outcome variables were cough and moderate/severe cough; the secondary outcome variable was any adverse event. Results: During the 6-week period, the risk of cough was lower in the genotyping group than in the control group [five (12.2%) and nine (33.3%) participants, respectively; hazard ratio: 0.25; log-rank P = 0.017]. The moderate/severe cough risk was also lower in the genotyping group [one (2.4%) and five (18.5%) participants, respectively; hazard ratio: 0.12; log-rank P = 0.025]. Differences in cough (hazard ratio: 0.56; log-rank P = 0.32) and moderate/severe cough risk (hazard ratio: 0.26; log-rank P = 0.19) between the low-risk and control groups were not significant. The risk of total adverse events was similar between any two groups. Conclusion: Cough risk was lower during genotype-guided treatment than during conventional treatment. These results support the utility of NELL1 variant data in clinical decision making to personalize renin-angiotensin system blocker therapy use. Trial registration: ClinicalTrials.gov number: NCT05535595 (retrospectively registered at September 7, 2022). | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | JOURNAL OF HYPERTENSION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Angiotensin-Converting Enzyme Inhibitors / adverse effects | - |
dc.subject.MESH | Cough / chemically induced | - |
dc.subject.MESH | Cough / drug therapy | - |
dc.subject.MESH | Cough / genetics | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension* / chemically induced | - |
dc.subject.MESH | Hypertension* / drug therapy | - |
dc.subject.MESH | Hypertension* / genetics | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Perindopril* / adverse effects | - |
dc.subject.MESH | Young Adult | - |
dc.title | A randomized trial of genotype-guided perindopril use | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.contributor.googleauthor | Chan Joo Lee | - |
dc.contributor.googleauthor | Yura Kang | - |
dc.contributor.googleauthor | Jung Mi Park | - |
dc.contributor.googleauthor | Ji Hyun Lee | - |
dc.identifier.doi | 10.1097/hjh.0000000000003536 | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A03238 | - |
dc.relation.journalcode | J01448 | - |
dc.identifier.eissn | 1473-5598 | - |
dc.identifier.pmid | 37602458 | - |
dc.identifier.url | https://journals.lww.com/jhypertension/fulltext/2023/11000/a_randomized_trial_of_genotype_guided_perindopril.13.aspx | - |
dc.contributor.alternativeName | Lee, Snag Hak | - |
dc.contributor.affiliatedAuthor | 이상학 | - |
dc.contributor.affiliatedAuthor | 이찬주 | - |
dc.citation.volume | 41 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1768 | - |
dc.citation.endPage | 1774 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HYPERTENSION, Vol.41(11) : 1768-1774, 2023-11 | - |
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