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Virtual reality-based monitoring test for MCI: A multicenter feasibility study

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dc.contributor.author김근유-
dc.contributor.author김우정-
dc.contributor.author석정호-
dc.contributor.author오주영-
dc.contributor.author이산-
dc.contributor.author하정희-
dc.date.accessioned2023-11-07T07:48:18Z-
dc.date.available2023-11-07T07:48:18Z-
dc.date.issued2023-01-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/196521-
dc.description.abstractObjectives: As the significance of the early diagnosis of mild cognitive impairment (MCI) has emerged, it is necessary to develop corresponding screening tools with high ecological validity and feasible biomarkers. Virtual reality (VR)-based cognitive assessment program, which is close to the daily life of the older adults, can be suitable screening tools for MCI with ecological validity and accessibility. Meanwhile, dehydroepiandrosterone (DHEA) has been observed at a low concentration in the older adults with dementia or cognitive decline, indicating its potential as a biomarker of MCI. This study aimed to determine the efficacy and usability of a VR cognitive assessment program and salivary DHEA for screening MCI. Methods: The VR cognitive assessment program and the traditional Montreal Cognitive Assessment (MOCA) test were performed on 12 patients with MCI and 108 healthy older adults. The VR program operates in a situation of caring for a grandchild, and evaluates the memory, attention, visuospatial, and executive functions. An analysis of covariance (ANCOVA), a partial correlation analysis, and receiving operating characteristic (ROC) curve analysis were conducted for statistical analysis. Results: According to the ANCOVA, no significant difference in MOCA scores was found between the normal and MCI groups (F = 2.36, p = 0.127). However, the VR total score of the MCI group was significantly lower than that of the normal group (F = 8.674, p = 0.004). There was a significant correlation between the MOCA and VR scores in the total and matched subdomain scores. The ROC curve analysis also showed a larger area under the curve (AUC) for the VR test (0.765) than for the MOCA test (0.598), and the sensitivity and specificity of the VR program were 0.833 and 0.722, respectively. Salivary DHEA was correlated with VR total (R 2 = 0.082, p = 0.01) and attention scores (R 2 = 0.086, p = 0.009). Conclusion: The VR cognitive test was as effective as the traditional MOCA test in the MCI classification and safe enough for older adults to perform, indicating its potential as a diagnostic tool. It has also been shown that salivary DHEA can be used as a biomarker for MCI.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN PSYCHIATRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleVirtual reality-based monitoring test for MCI: A multicenter feasibility study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학교실)-
dc.contributor.googleauthorSooah Jang-
dc.contributor.googleauthorSun-Woo Choi-
dc.contributor.googleauthorSang Joon Son-
dc.contributor.googleauthorJooyoung Oh-
dc.contributor.googleauthorJunghee Ha-
dc.contributor.googleauthorWoo Jung Kim-
dc.contributor.googleauthorHyun Woong Roh-
dc.contributor.googleauthorKeun You Kim-
dc.contributor.googleauthorSan Lee-
dc.contributor.googleauthorEunjin Jung-
dc.contributor.googleauthorWoojin Cha-
dc.contributor.googleauthorHeonjoo Chae-
dc.contributor.googleauthorSuzi Kang-
dc.contributor.googleauthorJi Hye Kwon-
dc.contributor.googleauthorIn-Young Kim-
dc.contributor.googleauthorJu-Yeal Lee-
dc.contributor.googleauthorHyun Kyung Shin-
dc.contributor.googleauthorJin Sun Ryu-
dc.contributor.googleauthorRyunsup Ahn-
dc.contributor.googleauthorChang Hyung Hong-
dc.contributor.googleauthorJeong-Ho Seok-
dc.identifier.doi10.3389/fpsyt.2022.1057513-
dc.contributor.localIdA06133-
dc.contributor.localIdA04906-
dc.contributor.localIdA01929-
dc.contributor.localIdA05289-
dc.contributor.localIdA05001-
dc.relation.journalcodeJ03491-
dc.identifier.eissn1664-0640-
dc.identifier.pmid36741575-
dc.subject.keywordDHEA-
dc.subject.keywordMOCA-
dc.subject.keywordcognitive assessment-
dc.subject.keywordmild cognitive impairment-
dc.subject.keywordscreening-
dc.subject.keywordvirtual reality-
dc.contributor.alternativeNameKim, Keun You-
dc.contributor.affiliatedAuthor김근유-
dc.contributor.affiliatedAuthor김우정-
dc.contributor.affiliatedAuthor석정호-
dc.contributor.affiliatedAuthor오주영-
dc.contributor.affiliatedAuthor이산-
dc.citation.volume13-
dc.citation.startPage1057513-
dc.identifier.bibliographicCitationFRONTIERS IN PSYCHIATRY, Vol.13 : 1057513, 2023-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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