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Resting-state prefrontal EEG biomarker in correlation with postoperative delirium in elderly patients

Authors
 Jeongmin Kim  ;  Sujung Park  ;  Keung-Nyun Kim  ;  Yoon Ha  ;  Sang-Jun Shin  ;  Wonseok Cha  ;  Ki-Young Lee  ;  Jungmi Choi  ;  Bon-Nyeo Koo 
Citation
 FRONTIERS IN AGING NEUROSCIENCE, Vol.15 : 1224264, 2023-09 
Journal Title
FRONTIERS IN AGING NEUROSCIENCE
Issue Date
2023-09
Keywords
elderly ; electroencephalography ; median dominant frequency ; postoperative complications ; postoperative delirium
Abstract
Postoperative delirium (POD) is associated with adverse outcomes in elderly patients after surgery. Electroencephalography (EEG) can be used to develop a potential biomarker for degenerative cerebral dysfunctions, including mild cognitive impairment and dementia. This study aimed to explore the relationship between preoperative EEG and POD. We included 257 patients aged >70 years who underwent spinal surgery. We measured the median dominant frequency (MDF), which is a resting-state EEG biomarker involving intrinsic alpha oscillations that reflect an idle cortical state, from the prefrontal regions. Additionally, the mini-mental state examination and Montreal cognitive assessment (MoCA) were performed before surgery as well as 5 days after surgery. For long-term cognitive function follow up, the telephone interview for cognitive status™ (TICS) was performed 1 month and 1 year after surgery. Fifty-two (20.2%) patients were diagnosed with POD. A multivariable logistic regression analysis that included age, MoCA score, Charlson comorbidity index score, Mini Nutritional Assessment, and the MDF as variables revealed that the MDF had a significant odds ratio of 0.48 (95% confidence interval 0.27-0.85). Among the patients with POD, the postoperative neurocognitive disorders could last up to 1 year. Low MDF on preoperative EEG was associated with POD in elderly patients undergoing surgery. EEG could be a novel potential tool for identifying patients at a high risk of POD.
Files in This Item:
T202305645.pdf Download
DOI
10.3389/fnagi.2023.1224264
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Koo, Bon-Nyeo(구본녀) ORCID logo https://orcid.org/0000-0002-3189-1673
Kim, Keung Nyun(김긍년)
Kim, Jeongmin(김정민) ORCID logo https://orcid.org/0000-0002-0468-8012
Park, Sujung(박수정) ORCID logo https://orcid.org/0000-0002-2249-3286
Lee, Ki Young(이기영) ORCID logo https://orcid.org/0000-0003-4893-3195
Ha, Yoon(하윤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/196508
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