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Electroencephalography characteristics related to risk of sudden unexpected death in epilepsy in patients with Dravet syndrome
DC Field | Value | Language |
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dc.contributor.author | 김세희 | - |
dc.date.accessioned | 2023-11-07T07:44:40Z | - |
dc.date.available | 2023-11-07T07:44:40Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196506 | - |
dc.description.abstract | Objective: To investigate the quantitative electroencephalography (EEG) features associated with a high risk of sudden unexpected death in epilepsy (SUDEP) in patients with Dravet syndrome (DS). Methods: Patients with DS and healthy controls (HCs) who underwent EEG were included in the study. EEG signals were recorded using a 21 channel digital EEG system, and pre-processed data were analyzed to identify quantitative EEG features associated with a high SUDEP risk. To assess the risk of SUDEP, SUDEP-7 scores were used. Results: A total of 64 patients with DS [38 males and 26 females, aged: 128.51 ± 75.50 months (range: 23-380 months)], and 13 HCs [7 males and 6 females, aged: 95.46 ± 86.48 months (range: 13-263 months)] were included. For the absolute band power, the theta power was significantly higher in the high-SUDEP group than in the low-SUDEP group in the central brain region. For the relative band power, the theta power was also significantly higher in the high-SUDEP group than in the low-SUDEP group in the central and occipital brain regions. The alpha power was significantly lower in the high-SUDEP group than in the low-SUDEP group in the central and parietal brain regions. Conclusion: Patients with high SUDEP-7 scores have different EEG features from those with low SUDEP-7 scores, suggesting that EEG may be used as a biomarker of SUDEP in DS. Significance: Early intervention in patients with DS at a high risk of SUDEP can reduce mortality and morbidity. Patients with high theta band powers warrant high-level supervision. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Electroencephalography characteristics related to risk of sudden unexpected death in epilepsy in patients with Dravet syndrome | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Jeong-Youn Kim | - |
dc.contributor.googleauthor | Jeongyoon Shin | - |
dc.contributor.googleauthor | Laehyun Kim | - |
dc.contributor.googleauthor | Se Hee Kim | - |
dc.identifier.doi | 10.3389/fneur.2023.1222721 | - |
dc.contributor.localId | A00611 | - |
dc.relation.journalcode | J02996 | - |
dc.identifier.eissn | 1664-2295 | - |
dc.identifier.pmid | 37745659 | - |
dc.subject.keyword | Dravet syndrome (DS) | - |
dc.subject.keyword | electroencephalography (EEG) | - |
dc.subject.keyword | epilepsy | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | sudden unexpected death in epilepsy (SUDEP) | - |
dc.contributor.alternativeName | Kim, Se Hee | - |
dc.contributor.affiliatedAuthor | 김세희 | - |
dc.citation.volume | 14 | - |
dc.citation.startPage | 1222721 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN NEUROLOGY, Vol.14 : 1222721, 2023-09 | - |
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