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Elevated morbidity and mortality in patients with chronic idiopathic hypophosphatemia: a nationwide cohort study
DC Field | Value | Language |
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dc.contributor.author | 이유미 | - |
dc.contributor.author | 홍남기 | - |
dc.date.accessioned | 2023-11-07T07:42:04Z | - |
dc.date.available | 2023-11-07T07:42:04Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196493 | - |
dc.description.abstract | Background: Chronic idiopathic hypophosphatemia (CIH) induced by X-linked hypophosphatemic rickets or tumor-induced osteomalacia is a rare inherited or acquired disorder. However, due to its rarity, little is known about the epidemiology and natural course of CIH. Therefore, we aimed to identify the prevalence and long-term health outcomes of CIH patients. Methods: Using the Korean Health Insurance Review and Assessment claims database, we evaluated the incidence of hypophosphatemia initially diagnosed from 2003 to 2018. After excluding secondary conditions that could change serum phosphorus levels, we identified 154 patients (76 men and 78 women) with non-secondary and non-renal hypophosphatemia. These hypophosphatemic patients were compared at a ratio of 1:10 with age-, sex-, and index-year-matched controls (n = 1,540). Results: In the distribution of age at diagnosis, a large peak was observed in patients aged 1-4 years and small peaks were observed in ages from 40-70 years. The age-standardized incidence rate showed non-statistically significant trend from 0.24 per 1,000,000 persons in 2003 to 0.30 in 2018. Hypophosphatemic patients had a higher risk of any complication (adjusted hazard ratio [aHR], 2.17; 95% confidence interval [CI], 1.67-2.69) including cardiovascular outcomes, chronic kidney disease, hyperparathyroidism, osteoporotic fractures, periodontitis, and depression. Hypophosphatemic patients also had higher risks of mortality and hospitalization than the controls (aHR, 3.26; 95% CI, 1.83-5.81; and aHR, 2.49; 95% CI, 1.97-3.16, respectively). Conclusion: This first nationwide study of CIH in South Korea found a bimodal age distribution and no sex differences among patients. Hypophosphatemic patients had higher risks of complications, mortality, and hospitalization compared to age- and sex-matched controls. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Research | - |
dc.relation.isPartOf | FRONTIERS IN ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Asian People | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Familial Hypophosphatemic Rickets* / complications | - |
dc.subject.MESH | Familial Hypophosphatemic Rickets* / epidemiology | - |
dc.subject.MESH | Familial Hypophosphatemic Rickets* / mortality | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypophosphatemia* / epidemiology | - |
dc.subject.MESH | Hypophosphatemia* / etiology | - |
dc.subject.MESH | Hypophosphatemia* / mortality | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Morbidity | - |
dc.subject.MESH | Republic of Korea | - |
dc.title | Elevated morbidity and mortality in patients with chronic idiopathic hypophosphatemia: a nationwide cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kyoung Jin Kim | - |
dc.contributor.googleauthor | Ji Eun Song | - |
dc.contributor.googleauthor | Ji Hyun Kim | - |
dc.contributor.googleauthor | Namki Hong | - |
dc.contributor.googleauthor | Sin Gon Kim | - |
dc.contributor.googleauthor | Juneyoung Lee | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.identifier.doi | 10.3389/fendo.2023.1229750 | - |
dc.contributor.localId | A03012 | - |
dc.contributor.localId | A04388 | - |
dc.relation.journalcode | J03412 | - |
dc.identifier.eissn | 1664-2392 | - |
dc.identifier.pmid | 37635983 | - |
dc.subject.keyword | comorbidity | - |
dc.subject.keyword | epidemiology | - |
dc.subject.keyword | hypophosphatemia | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | nationwide study | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | 이유미 | - |
dc.contributor.affiliatedAuthor | 홍남기 | - |
dc.citation.volume | 14 | - |
dc.citation.startPage | 1229750 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN ENDOCRINOLOGY, Vol.14 : 1229750, 2023-08 | - |
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