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Surgical margin status and role of adjuvant therapy in human papillomavirus-positive oropharyngeal cancer
DC Field | Value | Language |
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dc.contributor.author | 고윤우 | - |
dc.contributor.author | 김세헌 | - |
dc.contributor.author | 박영민 | - |
dc.contributor.author | 임재열 | - |
dc.contributor.author | 최은창 | - |
dc.date.accessioned | 2023-11-07T07:40:50Z | - |
dc.date.available | 2023-11-07T07:40:50Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196491 | - |
dc.description.abstract | Background: We analyzed the difference in treatment results according to safety margin range and studied the role of adjuvant therapy in patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC). Materials and methods: A total of 279 patients with HPV+ OPSCC were included in this study. Results: Surgical margin and T classification were significant prognostic factors related to death. The difference in locoregional recurrence was analyzed by dividing the safety margin into groups of <1, 1-5, and >5 mm. There was no significant difference in local-regional recurrence for T1-T2 lesions between the three groups. Adjuvant therapy can significantly reduce disease recurrence in HPV+ OPSCC patients with risk factors. Conclusions: In T1-T2 lesions without other risk factors, even with a safety margin ≥1 mm, adjuvant therapy can potentially be omitted. Adjuvant therapy can significantly reduce disease recurrence in HPV+ OPSCC patients with risk factors. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | John Wiley And Sons | - |
dc.relation.isPartOf | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Carcinoma, Squamous Cell* / pathology | - |
dc.subject.MESH | Head and Neck Neoplasms* | - |
dc.subject.MESH | Human Papillomavirus Viruses | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Margins of Excision | - |
dc.subject.MESH | Neoplasm Recurrence, Local / surgery | - |
dc.subject.MESH | Oropharyngeal Neoplasms* / pathology | - |
dc.subject.MESH | Oropharyngeal Neoplasms* / surgery | - |
dc.subject.MESH | Papillomaviridae | - |
dc.subject.MESH | Papillomavirus Infections* / complications | - |
dc.subject.MESH | Papillomavirus Infections* / pathology | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Squamous Cell Carcinoma of Head and Neck | - |
dc.title | Surgical margin status and role of adjuvant therapy in human papillomavirus-positive oropharyngeal cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | Young Min Park | - |
dc.contributor.googleauthor | Jae-Yol Lim | - |
dc.contributor.googleauthor | Yoon Woo Koh | - |
dc.contributor.googleauthor | Eun Chang Choi | - |
dc.contributor.googleauthor | Se-Heon Kim | - |
dc.identifier.doi | 10.1002/hed.27473 | - |
dc.contributor.localId | A00133 | - |
dc.contributor.localId | A00605 | - |
dc.contributor.localId | A01566 | - |
dc.contributor.localId | A03396 | - |
dc.contributor.localId | A04161 | - |
dc.relation.journalcode | J00963 | - |
dc.identifier.eissn | 1097-0347 | - |
dc.identifier.pmid | 37489048 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/hed.27473 | - |
dc.subject.keyword | HPV-positive oropharyngeal cancer | - |
dc.subject.keyword | adjuvant therapy | - |
dc.subject.keyword | neoadjuvant chemotherapy | - |
dc.subject.keyword | safety margin | - |
dc.contributor.alternativeName | Koh, Yoon Woo | - |
dc.contributor.affiliatedAuthor | 고윤우 | - |
dc.contributor.affiliatedAuthor | 김세헌 | - |
dc.contributor.affiliatedAuthor | 박영민 | - |
dc.contributor.affiliatedAuthor | 임재열 | - |
dc.contributor.affiliatedAuthor | 최은창 | - |
dc.citation.volume | 45 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2369 | - |
dc.citation.endPage | 2376 | - |
dc.identifier.bibliographicCitation | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.45(9) : 2369-2376, 2023-09 | - |
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