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Hepatic steatosis index at diagnosis has the potential for forecasting end-stage kidney disease in patients with antineutrophil cytoplasmic antibody-associated vasculitis
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 이상원 | - |
dc.date.accessioned | 2023-11-07T07:28:45Z | - |
dc.date.available | 2023-11-07T07:28:45Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 2093-940X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196432 | - |
dc.description.abstract | Objective: This study evaluated whether the hepatic steatosis index (HSI) at antineutrophil cytoplasmic antibody-associated vasculitis (AAV) diagnosis could forecast poor outcomes during the disease course in AAV patients. Methods: This study included 260 AAV patients. The equation for HSI is as follows HSI=8×(alanine aminotransferase/aspartate aminotransferase)+body mass index+(2, diabetes mellitus)+(2, female). The cut-off of HSI was obtained using the receiver operating characteristic curve. Results: The median age of the 260 patients was 59.5 years, and 65.0% were female. Among the continuous variables excluding the parameters composing the equation for HSI, HSI was significantly correlated with Birmingham vasculitis activity score, five-factor score, haemoglobin, blood urea nitrogen, serum creatinine, and total cholesterol. Among poor outcomes, the area under the curve of HSI for end-stage renal disease (ESRD) was significant, and the cut-off of HSI for ESRD was set at ≤30.82. AAV patients with HSI ≤30.82 exhibited a significantly higher risk of ESRD (relative risk 3.489) and a significantly lower cumulative ESRD-free survival rate than those with HSI >30.82. Conclusion: This study is the first to demonstrate that HSI at AAV diagnosis could forecast ESRD during the disease course in AAV patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한류마티스학회 | - |
dc.relation.isPartOf | Journal of Rheumatic Diseases | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Hepatic steatosis index at diagnosis has the potential for forecasting end-stage kidney disease in patients with antineutrophil cytoplasmic antibody-associated vasculitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyun Joon Choi | - |
dc.contributor.googleauthor | Pil Gyu Park | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Ji Hye Huh | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.identifier.doi | 10.4078/jrd.2023.0032 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02824 | - |
dc.relation.journalcode | J01737 | - |
dc.identifier.eissn | 2233-4718 | - |
dc.identifier.pmid | 37736592 | - |
dc.subject.keyword | Antineutrophil cytoplasmic antibody | - |
dc.subject.keyword | End-stage renal disease | - |
dc.subject.keyword | Forecasting | - |
dc.subject.keyword | Hepatic steatosis index | - |
dc.subject.keyword | Vasculitis | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | 박용범 | - |
dc.contributor.affiliatedAuthor | 이상원 | - |
dc.citation.volume | 30 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 260 | - |
dc.citation.endPage | 267 | - |
dc.identifier.bibliographicCitation | Journal of Rheumatic Diseases, Vol.30(4) : 260-267, 2023-10 | - |
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