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The third dose of measles-containing vaccine induces robust immune responses against measles in young seronegative healthcare workers who had previous two-dose measles vaccination
DC Field | Value | Language |
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dc.contributor.author | 김용찬 | - |
dc.contributor.author | 최준용 | - |
dc.date.accessioned | 2023-11-07T07:26:01Z | - |
dc.date.available | 2023-11-07T07:26:01Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 1876-0341 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196421 | - |
dc.description.abstract | Background: Despite the low measles antibody positivity rate among young healthcare workers (HCWs) who have previously received two doses of a measles-containing vaccine (MCV), whether an additional dose of MCV acts as a booster remains unknown. Thus, we aimed to evaluate the immune responses to a third dose of MCV in young HCWs. Methods: Hospital-wide measles seroprevalence was assessed using enzyme-linked immunosorbent assay (ELISA). The immunogenicity of a third dose of MCV was determined in young seronegative HCWs (born between 1986 and 1997) who had previously received a two-dose measles vaccination. Results: A total of 3033 (92.6%) HCWs had anti-measles immunoglobulin G. The lowest seropositivity rate was observed in HCWs aged 20-24 years (87.7%). In this group, HCWs who received a third dose of MCV had higher seropositivity than those who received a second dose (89.5% vs. 75.4%). A third dose of MCV was administered to 18 HCWs who did not have anti-measles IgG despite two doses. Neutralizing antibody titers increased significantly 4 weeks after the third vaccination. Although neutralizing antibody titers decreased 1 year post vaccination, 17 (94.4%) HCWs had medium (121-900 mIU/mL) or high (>900 mIU/mL) levels. Furthermore, the third dose of MCV increased the measles virus-specific T-cell effector function. Conclusions: The third dose of MCV induced a strong immune response against measles in young seronegative HCWs who had previously received a two-dose measles vaccination. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF INFECTION AND PUBLIC HEALTH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Antibodies, Neutralizing | - |
dc.subject.MESH | Health Personnel | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Measles Vaccine* | - |
dc.subject.MESH | Measles* / prevention & control | - |
dc.subject.MESH | Seroepidemiologic Studies | - |
dc.subject.MESH | Vaccination | - |
dc.title | The third dose of measles-containing vaccine induces robust immune responses against measles in young seronegative healthcare workers who had previous two-dose measles vaccination | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yong Chan Kim | - |
dc.contributor.googleauthor | Heejin Nam | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Eui-Cheol Shin | - |
dc.contributor.googleauthor | Young Hwa Choi | - |
dc.identifier.doi | 10.1016/j.jiph.2023.08.002 | - |
dc.contributor.localId | A00752 | - |
dc.contributor.localId | A04191 | - |
dc.relation.journalcode | J04249 | - |
dc.identifier.eissn | 1876-035X | - |
dc.identifier.pmid | 37597451 | - |
dc.subject.keyword | Immunogenicity | - |
dc.subject.keyword | Measles | - |
dc.subject.keyword | Measles vaccine | - |
dc.subject.keyword | Safety | - |
dc.subject.keyword | Seroprevalence | - |
dc.contributor.alternativeName | Kim, Yong Chan | - |
dc.contributor.affiliatedAuthor | 김용찬 | - |
dc.contributor.affiliatedAuthor | 최준용 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1643 | - |
dc.citation.endPage | 1649 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFECTION AND PUBLIC HEALTH, Vol.16(10) : 1643-1649, 2023-10 | - |
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