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The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis
DC Field | Value | Language |
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dc.contributor.author | 박무석 | - |
dc.contributor.author | 박수연 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 심효섭 | - |
dc.contributor.author | 윤호근 | - |
dc.contributor.author | 이승현 | - |
dc.contributor.author | 이수연 | - |
dc.date.accessioned | 2023-10-19T06:07:20Z | - |
dc.date.available | 2023-10-19T06:07:20Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196362 | - |
dc.description.abstract | Idiopathic pulmonary fibrosis (IPF) is a chronic, fatal, fibrotic, interstitial lung disease of unknown cause. Despite extensive studies, the underlying mechanisms of IPF development remain unknown. Here, we found that p300 was upregulated in multiple epithelial cells in lung samples from patients with IPF and mouse models of lung fibrosis. Lung fibrosis was significantly diminished by the alveolar type II (ATII) cell-specific deletion of the p300 gene. Moreover, we found that ubiquitin C-terminal hydrolase L3 (UCHL3)-mediated deubiquitination of p300 led to the transcriptional activation of the chemokines Ccl2, Ccl7, and Ccl12 through the cooperative action of p300 and C/EBPβ, which consequently promoted M2 macrophage polarization. Selective blockade of p300 activity in ATII cells resulted in the reprogramming of M2 macrophages into antifibrotic macrophages. These findings demonstrate a pivotal role for p300 in the development of lung fibrosis and suggest that p300 could serve as a promising target for IPF treatment. © 2023. The Author(s). | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Alveolar Epithelial Cells* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Chemokine CCL2 / genetics | - |
dc.subject.MESH | Deubiquitinating Enzymes | - |
dc.subject.MESH | E1A-Associated p300 Protein | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Idiopathic Pulmonary Fibrosis* / genetics | - |
dc.subject.MESH | Lung | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Ubiquitin Thiolesterase* / metabolism | - |
dc.title | The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Soo Yeon Lee | - |
dc.contributor.googleauthor | Soo-Yeon Park | - |
dc.contributor.googleauthor | Seung-Hyun Lee | - |
dc.contributor.googleauthor | Hyunsik Kim | - |
dc.contributor.googleauthor | Jae-Hwan Kwon | - |
dc.contributor.googleauthor | Jung-Yoon Yoo | - |
dc.contributor.googleauthor | Kyunggon Kim | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.contributor.googleauthor | Chun Geun Lee | - |
dc.contributor.googleauthor | Jack A Elias | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Hyo Sup Shim | - |
dc.contributor.googleauthor | Ho-Geun Yoon | - |
dc.identifier.doi | 10.1038/s12276-023-01066-1 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A01534 | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A02932 | - |
dc.relation.journalcode | J00860 | - |
dc.identifier.eissn | 2092-6413 | - |
dc.identifier.pmid | 37524875 | - |
dc.contributor.alternativeName | Park, Moo Suk | - |
dc.contributor.affiliatedAuthor | 박무석 | - |
dc.contributor.affiliatedAuthor | 박수연 | - |
dc.contributor.affiliatedAuthor | 손명현 | - |
dc.contributor.affiliatedAuthor | 심효섭 | - |
dc.contributor.affiliatedAuthor | 윤호근 | - |
dc.contributor.affiliatedAuthor | 이승현 | - |
dc.citation.volume | 55 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1795 | - |
dc.citation.endPage | 1805 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.55(8) : 1795-1805, 2023-08 | - |
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