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Estimating Age-Specific Mean Sojourn Time of Breast Cancer and Sensitivity of Mammographic Screening by Breast Density among Korean Women

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dc.contributor.author박소희-
dc.date.accessioned2023-10-19T05:50:08Z-
dc.date.available2023-10-19T05:50:08Z-
dc.date.issued2023-01-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/196290-
dc.description.abstractPurpose: High breast cancer incidence and dense breast prevalence among women in forties are specific to Asian. This study examined the natural history of breast cancer among Korean women. Materials and methods: We applied a three-state Markov model (i.e., healthy, preclinical, and clinical state) to fit the natural history of breast cancer to data in the Korean National Cancer Screening Program. Breast cancer was ascertained by linkage to the Korean Central Cancer Registry. Disease-progression rates (i.e., transition rates between three states), mean sojourn time (MST) and mammographic sensitivity were estimated across 10-year age groups and levels of breast density determined by the Breast Imaging, Reporting and Data System. Results: Overall prevalence of dense breast was 53.9%. Transition rate from healthy to preclinical state, indicating the preclinical incidence of breast cancer, was higher among women in forties (0.0019; 95% confidence interval [CI], 0.0017 to 0.0021) and fifties (0.0020; 95% CI, 0.0017 to 0.0022), than women in sixties (0.0014; 95% CI, 0.0012 to 0.0017). The MSTs, in which the tumor is asymptomatic but detectable by screening, were also fastest among younger age groups, estimated as 1.98 years (95% CI, 1.67 to 2.33), 2.49 years (95% CI, 1.92 to 3.22), and 3.07 years (95% CI, 2.11 to 4.46) for women in forties, fifties, and sixties, respectively. Having dense breasts increased the likelihood of the preclinical cancer risk (1.96 to 2.35 times) and decreased the duration of MST (1.53 to 2.02 times). Conclusion: This study estimated Korean-specific natural history parameters of breast cancer that would be utilized for establishing optimal screening strategies in countries with higher dense breast prevalence.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAge Factors-
dc.subject.MESHBreast Density-
dc.subject.MESHBreast Neoplasms* / diagnostic imaging-
dc.subject.MESHBreast Neoplasms* / epidemiology-
dc.subject.MESHChild, Preschool-
dc.subject.MESHEarly Detection of Cancer-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHMammography-
dc.subject.MESHMass Screening / methods-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.titleEstimating Age-Specific Mean Sojourn Time of Breast Cancer and Sensitivity of Mammographic Screening by Breast Density among Korean Women-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorEunji Choi-
dc.contributor.googleauthorMina Suh-
dc.contributor.googleauthorSo-Youn Jung-
dc.contributor.googleauthorKyu-Won Jung-
dc.contributor.googleauthorSohee Park-
dc.contributor.googleauthorJae Kwan Jun-
dc.contributor.googleauthorKui Son Choi-
dc.identifier.doi10.4143/crt.2021.962-
dc.contributor.localIdA01531-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid35381162-
dc.subject.keywordBreast density-
dc.subject.keywordMammography-
dc.subject.keywordMean sojourn time-
dc.subject.keywordNatural history-
dc.subject.keywordScreening sensitivity-
dc.contributor.alternativeNamePark, So Hee-
dc.contributor.affiliatedAuthor박소희-
dc.citation.volume55-
dc.citation.number1-
dc.citation.startPage136-
dc.citation.endPage144-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.55(1) : 136-144, 2023-01-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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